Update in atherothrombotic disease

Juan Viles Gonzalez, Sunil X. Anand, Carolina Valdiviezo, Urooj Zafar, Randolf Hutter, Javier Sanz, Teresa Rius, Michael Poon, Valentin Fuster, Juan J. Badimon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Crucial advances in our understanding of the pathogenesis of atherothrombosis, defined as atherosclerosis and its thrombotic complications, have been achieved during the past two decades. The historical hypothesis of pathogenesis ("lipid accumulation") has evolved to integrate several factors contributing to the initiation and evolution of this complex disease. Endothelial dysfunction is considered to be the earliest event in atherogenesis. Inflammation and apoptosis play critical roles in its progression and onset. Tissue factor is postulated to be a central actor in determining plaque thrombogenicity. A hyperreactive state of the blood ("vulnerable blood") may be responsible for one-third of all the acute coronary syndromes. This review will discuss emerging concepts in the pathogenesis of and therapeutic approaches to atherothrombotic disease.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalMount Sinai Journal of Medicine
Volume71
Issue number3
StatePublished - May 1 2004
Externally publishedYes

Fingerprint

Atherosclerosis
Thromboplastin
Acute Coronary Syndrome
Apoptosis
Inflammation
Lipids
Therapeutics

Keywords

  • Acute coronary syndromes
  • Antithrombotic therapy
  • Apoptosis
  • Atherosclerosis
  • Atherothrombosis
  • Coronary artery disease
  • Endothelial dysfunction
  • Inflammation
  • Tissue factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Viles Gonzalez, J., Anand, S. X., Valdiviezo, C., Zafar, U., Hutter, R., Sanz, J., ... Badimon, J. J. (2004). Update in atherothrombotic disease. Mount Sinai Journal of Medicine, 71(3), 197-208.

Update in atherothrombotic disease. / Viles Gonzalez, Juan; Anand, Sunil X.; Valdiviezo, Carolina; Zafar, Urooj; Hutter, Randolf; Sanz, Javier; Rius, Teresa; Poon, Michael; Fuster, Valentin; Badimon, Juan J.

In: Mount Sinai Journal of Medicine, Vol. 71, No. 3, 01.05.2004, p. 197-208.

Research output: Contribution to journalArticle

Viles Gonzalez, J, Anand, SX, Valdiviezo, C, Zafar, U, Hutter, R, Sanz, J, Rius, T, Poon, M, Fuster, V & Badimon, JJ 2004, 'Update in atherothrombotic disease', Mount Sinai Journal of Medicine, vol. 71, no. 3, pp. 197-208.
Viles Gonzalez J, Anand SX, Valdiviezo C, Zafar U, Hutter R, Sanz J et al. Update in atherothrombotic disease. Mount Sinai Journal of Medicine. 2004 May 1;71(3):197-208.
Viles Gonzalez, Juan ; Anand, Sunil X. ; Valdiviezo, Carolina ; Zafar, Urooj ; Hutter, Randolf ; Sanz, Javier ; Rius, Teresa ; Poon, Michael ; Fuster, Valentin ; Badimon, Juan J. / Update in atherothrombotic disease. In: Mount Sinai Journal of Medicine. 2004 ; Vol. 71, No. 3. pp. 197-208.
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