uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation

Dan Ilkovitch, Roberto Carrio, Diana M. Lopez

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Myeloid-derived suppressor cells (MDSC) have been shown to play a critical role in tumor-induced immunosuppression, in many mouse and human cancers. The aim of this study was to show that MDSC accumulation is tumor burden-dependent, and to investigate the role of the tumor-derived urokinase plasminogen activator (uPA) and its receptor (uPAR) on MDSC recruitment. Materials and Methods: Levels of MDSC were assessed in tumor-bearers, and the ability to recruit MDSC by uPA was investigated in normal, tumor-bearers, uPAR-/-, and CD11b-/- mice. uPAR expression in MDSC was also explored. Results: MDSC accumulate to dramatic levels in tumor-bearers, and tumor-derived factors such as uPA also increase to great levels in circulation. MDSC can be recruited by uPA, and uPAR but not CD11b are required for such recruitment. Conclusion: MDSC accumulation is tumor burden-dependent, and tumor-derived factors such as uPA and its receptor uPAR play a role in their recruitment.

Original languageEnglish (US)
Pages (from-to)4263-4270
Number of pages8
JournalAnticancer research
Volume32
Issue number10
StatePublished - Oct 2012

Keywords

  • Bone marrow
  • MDSC
  • Myeloid-derived suppressor cells
  • uPA
  • uPA receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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