Abstract
The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Molecular Brain Research |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1 1997 |
Keywords
- Cocaine
- Dopamine
- Excited delirium
- Human brain
- Polymerase chain reaction
- Receptor
- Reverse transcription
- Ribonuclease protection assay
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
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Cite this
Segal, D. M., Moraes, C. T., & Mash, D. C. (1997). Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities. Molecular Brain Research, 45(2), 335-339. https://doi.org/10.1016/S0169-328X(97)00025-9