Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities

David M. Segal; Carlos T. Moraes; Deborah C. Mash

doi:10.1016/S0169-328X(97)00025-9

Up-regulation of D₃ dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities

David M. Segal, Carlos T. Moraes, Deborah C. Mash

Neurology

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

The effects of chronic cocaine use on D₃ receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D₃ receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D₃ receptor mRNA in a critical reward center in brain.

Original language	English (US)
Pages (from-to)	335-339
Number of pages	5
Journal	Molecular Brain Research
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(97)00025-9
State	Published - May 1997

Keywords

Cocaine
Dopamine
Excited delirium
Human brain
Polymerase chain reaction
Receptor
Reverse transcription
Ribonuclease protection assay

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(97)00025-9

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AB - The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.

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KW - Excited delirium

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KW - Polymerase chain reaction

KW - Receptor

KW - Reverse transcription

KW - Ribonuclease protection assay

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