Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities

David M. Segal, Carlos T. Moraes, Deborah C. Mash

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalMolecular Brain Research
Volume45
Issue number2
DOIs
StatePublished - May 1 1997

Keywords

  • Cocaine
  • Dopamine
  • Excited delirium
  • Human brain
  • Polymerase chain reaction
  • Receptor
  • Reverse transcription
  • Ribonuclease protection assay

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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