Abstract
The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.
Original language | English (US) |
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Pages (from-to) | 335-339 |
Number of pages | 5 |
Journal | Molecular Brain Research |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - May 1997 |
Keywords
- Cocaine
- Dopamine
- Excited delirium
- Human brain
- Polymerase chain reaction
- Receptor
- Reverse transcription
- Ribonuclease protection assay
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience