Abstract
Objective: Due to overlapping, temporal information is mostly lost in high rate steady-state pattern electroretinograms (PERG<inf>SS</inf>). This study develops a deconvolution method and a display/recording system to "unwrap" PERG<inf>SS</inf> and obtain a transient, "per stimulus" response (PERG<inf>tr</inf>) regardless of reversal rate. Methods: Processing and instrumentation, including high temporal resolution display and acquisition were developed for deconvolving PERGs acquired at high rates by slight jittering of reversal onsets at a given mean rate. Results: The system was successfully tested at eight rates from 2.2 to 78.1. rps. At medium rates (17.4-41.2. rps) recordings with conventional morphology (N35-P50-N95) but earlier peaks and higher amplitudes were extracted up to 40. rps. At higher rates, smaller triphasic responses were obtained, exhibiting similar peak latencies, but reversed polarity. Oscillating potentials (OPs) were also recorded at all rates after deconvolution. Conclusions: Transient PERGs and OPs can be extracted from quasi steady-state PERG recordings obtained at high rates with a deconvolution algorithm using high temporal resolution display and acquisition systems. Significance: The methodology to extract transient and oscillatory responses from steady-state PERGs could be useful in understanding high rate responses and diagnosis of various retinal diseases by revealing temporal information on waveform components which cannot be normally observed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2079-2089 |
| Number of pages | 11 |
| Journal | Clinical Neurophysiology |
| Volume | 125 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2014 |
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Keywords
- Deconvolution
- High rate electroretinography
- Oscillatory responses
- Pattern electroretinogram
- Steady-state PERGs
- Unwrapping
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Sensory Systems
Cite this
Unwrapping of transient responses from high rate overlapping pattern electroretinograms by deconvolution. / Toft-Nielsen, Jonathon; Bohorquez, Jorge; Ozdamar, Ozcan.
In: Clinical Neurophysiology, Vol. 125, No. 10, 01.10.2014, p. 2079-2089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unwrapping of transient responses from high rate overlapping pattern electroretinograms by deconvolution
AU - Toft-Nielsen, Jonathon
AU - Bohorquez, Jorge
AU - Ozdamar, Ozcan
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective: Due to overlapping, temporal information is mostly lost in high rate steady-state pattern electroretinograms (PERGSS). This study develops a deconvolution method and a display/recording system to "unwrap" PERGSS and obtain a transient, "per stimulus" response (PERGtr) regardless of reversal rate. Methods: Processing and instrumentation, including high temporal resolution display and acquisition were developed for deconvolving PERGs acquired at high rates by slight jittering of reversal onsets at a given mean rate. Results: The system was successfully tested at eight rates from 2.2 to 78.1. rps. At medium rates (17.4-41.2. rps) recordings with conventional morphology (N35-P50-N95) but earlier peaks and higher amplitudes were extracted up to 40. rps. At higher rates, smaller triphasic responses were obtained, exhibiting similar peak latencies, but reversed polarity. Oscillating potentials (OPs) were also recorded at all rates after deconvolution. Conclusions: Transient PERGs and OPs can be extracted from quasi steady-state PERG recordings obtained at high rates with a deconvolution algorithm using high temporal resolution display and acquisition systems. Significance: The methodology to extract transient and oscillatory responses from steady-state PERGs could be useful in understanding high rate responses and diagnosis of various retinal diseases by revealing temporal information on waveform components which cannot be normally observed.
AB - Objective: Due to overlapping, temporal information is mostly lost in high rate steady-state pattern electroretinograms (PERGSS). This study develops a deconvolution method and a display/recording system to "unwrap" PERGSS and obtain a transient, "per stimulus" response (PERGtr) regardless of reversal rate. Methods: Processing and instrumentation, including high temporal resolution display and acquisition were developed for deconvolving PERGs acquired at high rates by slight jittering of reversal onsets at a given mean rate. Results: The system was successfully tested at eight rates from 2.2 to 78.1. rps. At medium rates (17.4-41.2. rps) recordings with conventional morphology (N35-P50-N95) but earlier peaks and higher amplitudes were extracted up to 40. rps. At higher rates, smaller triphasic responses were obtained, exhibiting similar peak latencies, but reversed polarity. Oscillating potentials (OPs) were also recorded at all rates after deconvolution. Conclusions: Transient PERGs and OPs can be extracted from quasi steady-state PERG recordings obtained at high rates with a deconvolution algorithm using high temporal resolution display and acquisition systems. Significance: The methodology to extract transient and oscillatory responses from steady-state PERGs could be useful in understanding high rate responses and diagnosis of various retinal diseases by revealing temporal information on waveform components which cannot be normally observed.
KW - Deconvolution
KW - High rate electroretinography
KW - Oscillatory responses
KW - Pattern electroretinogram
KW - Steady-state PERGs
KW - Unwrapping
UR - http://www.scopus.com/inward/record.url?scp=84927174164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927174164&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2014.02.002
DO - 10.1016/j.clinph.2014.02.002
M3 - Article
C2 - 24618216
AN - SCOPUS:84927174164
VL - 125
SP - 2079
EP - 2089
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 10
ER -