TY - JOUR
T1 - Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells
AU - Summerhayes, I. C.
AU - Lampidis, T. J.
AU - Bernal, S. D.
AU - Nadakavukaren, J. J.
AU - Nadakavukaren, K. K.
AU - Shepherd, E. L.
AU - Chen, L. B.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long (3-5 days) retention times of rhodamine 123, a mitochondria-specific fluorescent probe, in living cells. Among 50 keratin-positive carcinoma or transformed epithelial cell lines tested, mitochondria with prolonged rhodamine 123 retention are detected in most of the transitional cell carcinoma, adenocarcinoma, and chemical carcinogen-transformed epithelial cell lines and in some squamous cell carcinoma lines but not in any oat cell carcinoma lines. The presence of mitochondria having unusual dye retention may be useful for diagnosis and exploitable for chemotherapy of certain human carcinomas.
AB - Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long (3-5 days) retention times of rhodamine 123, a mitochondria-specific fluorescent probe, in living cells. Among 50 keratin-positive carcinoma or transformed epithelial cell lines tested, mitochondria with prolonged rhodamine 123 retention are detected in most of the transitional cell carcinoma, adenocarcinoma, and chemical carcinogen-transformed epithelial cell lines and in some squamous cell carcinoma lines but not in any oat cell carcinoma lines. The presence of mitochondria having unusual dye retention may be useful for diagnosis and exploitable for chemotherapy of certain human carcinomas.
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U2 - 10.1073/pnas.79.17.5292
DO - 10.1073/pnas.79.17.5292
M3 - Article
C2 - 6752944
AN - SCOPUS:0344789509
VL - 79
SP - 5292
EP - 5296
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 17 I
ER -