Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

I. C. Summerhayes; T. J. Lampidis; S. D. Bernal; J. J. Nadakavukaren; K. K. Nadakavukaren; E. L. Shepherd; L. B. Chen

doi:10.1073/pnas.79.17.5292

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

I. C. Summerhayes, T. J. Lampidis, S. D. Bernal, J. J. Nadakavukaren, K. K. Nadakavukaren, E. L. Shepherd, L. B. Chen

Research output: Contribution to journal › Article › peer-review

328 Scopus citations

Abstract

Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long (3-5 days) retention times of rhodamine 123, a mitochondria-specific fluorescent probe, in living cells. Among 50 keratin-positive carcinoma or transformed epithelial cell lines tested, mitochondria with prolonged rhodamine 123 retention are detected in most of the transitional cell carcinoma, adenocarcinoma, and chemical carcinogen-transformed epithelial cell lines and in some squamous cell carcinoma lines but not in any oat cell carcinoma lines. The presence of mitochondria having unusual dye retention may be useful for diagnosis and exploitable for chemotherapy of certain human carcinomas.

Original language	English (US)
Pages (from-to)	5292-5296
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	17 I
DOIs	https://doi.org/10.1073/pnas.79.17.5292
State	Published - 1982
Externally published	Yes

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Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. / Summerhayes, I. C.; Lampidis, T. J.; Bernal, S. D.; Nadakavukaren, J. J.; Nadakavukaren, K. K.; Shepherd, E. L.; Chen, L. B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 17 I, 1982, p. 5292-5296.

Research output: Contribution to journal › Article › peer-review

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abstract = "Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long (3-5 days) retention times of rhodamine 123, a mitochondria-specific fluorescent probe, in living cells. Among 50 keratin-positive carcinoma or transformed epithelial cell lines tested, mitochondria with prolonged rhodamine 123 retention are detected in most of the transitional cell carcinoma, adenocarcinoma, and chemical carcinogen-transformed epithelial cell lines and in some squamous cell carcinoma lines but not in any oat cell carcinoma lines. The presence of mitochondria having unusual dye retention may be useful for diagnosis and exploitable for chemotherapy of certain human carcinomas.",

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AU - Nadakavukaren, K. K.

AU - Shepherd, E. L.

AU - Chen, L. B.

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