Unusual dose-related effect of an endorphin analog in a complex maze

Abba J. Kastin; Michael D. Mauk; Andrew V. Schally; David H. Coy

doi:10.1016/0031-9384(80)90317-0

Unusual dose-related effect of an endorphin analog in a complex maze

Abba J. Kastin, Michael D. Mauk, Andrew V. Schally, David H. Coy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Hungry adult rats were tested in a 12-choice maze for their ability to find a reward of food 15 minutes after being injected peripherally with (D-Ala²)-β-endorphin. Injection of the endorphin analog in a dose of 80 μg/kg body weight resulted in rats running the maze significantly slower and with more errors than rats injected with diluent. Animals receiving a dose ten times larger (800 μg/kg) were indistinguishable from controls in both running speed and errors, thus making a toxic effect unlikely. Possible changes in appetite, thirst, olfaction, emotionality, and general motor activity did not seem to explain the results. The inverted U-shaped dose-related response seemed to represent a variant from previous observations with CNS-active peptides in that the smaller dose impaired rather than enhanced performance.

Original language	English (US)
Pages (from-to)	959-962
Number of pages	4
Journal	Physiology AND Behavior
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/0031-9384(80)90317-0
State	Published - Jan 1 1980
Externally published	Yes

Keywords

Activity
Behavior
CNS
Dose-response
Learning
Maze
Opiate
Peptide

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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abstract = "Hungry adult rats were tested in a 12-choice maze for their ability to find a reward of food 15 minutes after being injected peripherally with (D-Ala2)-β-endorphin. Injection of the endorphin analog in a dose of 80 μg/kg body weight resulted in rats running the maze significantly slower and with more errors than rats injected with diluent. Animals receiving a dose ten times larger (800 μg/kg) were indistinguishable from controls in both running speed and errors, thus making a toxic effect unlikely. Possible changes in appetite, thirst, olfaction, emotionality, and general motor activity did not seem to explain the results. The inverted U-shaped dose-related response seemed to represent a variant from previous observations with CNS-active peptides in that the smaller dose impaired rather than enhanced performance.",

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AU - Schally, Andrew V.

AU - Coy, David H.

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Unusual dose-related effect of an endorphin analog in a complex maze

Abstract

Keywords

ASJC Scopus subject areas

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