Unmyelinated axon subpopulations in the rat peripheral nervous system

D. Chad, C. Rasool, Walter G Bradley, P. Good, S. Reichlin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Using the neurotoxin capsaicin, we examined subpopulations of unmyelinated axons in mixed (sciatic), cutaneous (sural), and muscular (nerve to soleus) nerves. Administration of capsaicin to neonatal rats caused reduction of the sciatic nerve immunoreactive (IR)-substance P (by 45%) and IR-somatostatin (by 84%) contents. This correlated with a substantial reduction in unmyelinated axons in the sciatic and sural nerves (45% and 65%, respectively), although there was no significant decrease in unmyelinated axons in the nerve to soleus. In a parallel study, we have shown that sympathetic ganglia-derived unmyelinated axons account for about 20 to 25% of the total unmyelinated axon population in both the sural nerve and the nerve to soleus. Thus, in the sural nerve, the majority of unmyelinated axons are dorsal root ganglia-derived, contain either substance P or somatostatin, and are capsaicin-sensitive; whereas in the nerve to soleus, the majority of unmyelinated axons are dorsal root ganglia-derived but are insensitive to capsaicin and do not contain substance P or somatostatin. These latter unmyelinated axons presumably contain a yet to be defined neurotransmitter and may be the axons connecting with muscular ergoreceptors, a subpopulation of unmyelinated axons that are biochemically and functionally distinct from the unmyelinated axons of cutaneous nerves.

Original languageEnglish
Pages (from-to)848-852
Number of pages5
JournalNeurology
Volume33
Issue number7
StatePublished - Aug 25 1983
Externally publishedYes

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Peripheral Nervous System
Axons
Sural Nerve
Capsaicin
Substance P
Somatostatin
Spinal Ganglia
Sciatic Nerve
Skin
Sympathetic Ganglia
Neurotoxins
Neurotransmitter Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chad, D., Rasool, C., Bradley, W. G., Good, P., & Reichlin, S. (1983). Unmyelinated axon subpopulations in the rat peripheral nervous system. Neurology, 33(7), 848-852.

Unmyelinated axon subpopulations in the rat peripheral nervous system. / Chad, D.; Rasool, C.; Bradley, Walter G; Good, P.; Reichlin, S.

In: Neurology, Vol. 33, No. 7, 25.08.1983, p. 848-852.

Research output: Contribution to journalArticle

Chad, D, Rasool, C, Bradley, WG, Good, P & Reichlin, S 1983, 'Unmyelinated axon subpopulations in the rat peripheral nervous system', Neurology, vol. 33, no. 7, pp. 848-852.
Chad D, Rasool C, Bradley WG, Good P, Reichlin S. Unmyelinated axon subpopulations in the rat peripheral nervous system. Neurology. 1983 Aug 25;33(7):848-852.
Chad, D. ; Rasool, C. ; Bradley, Walter G ; Good, P. ; Reichlin, S. / Unmyelinated axon subpopulations in the rat peripheral nervous system. In: Neurology. 1983 ; Vol. 33, No. 7. pp. 848-852.
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