Unmet Educational Needs and Clinical Practice Gaps in the Management of Generalized Pustular Psoriasis: Global Perspectives from the Front Line

Bruce Strober, Joyce Leman, Maja Mockenhaupt, Juliana Nakano de Melo, Ahmed Nassar, Vimal H. Prajapati, Paolo Romanelli, Julien Seneschal, Athanasios Tsianakas, Lee Yoong Wei, Masahito Yasuda, Ning Yu, Ana C. Hernandez Daly, Yukari Okubo

Research output: Contribution to journalArticlepeer-review


Introduction: Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening, neutrophilic, autoinflammatory skin disease characterised by recurrent flares of generalised sterile pustules and associated systemic features. Inconsistent diagnostic criteria and a lack of approved therapies pose serious challenges to GPP management. Our objectives were to discuss the challenges encountered in the care of patients with GPP and identify healthcare provider (HCP) educational needs and clinical practice gaps in GPP management. Methods: On 24 July 2020, 13 dermatologists from 10 countries (Brazil, Canada, China, Egypt, France, Germany, Japan, Malaysia, the UK and the USA) attended a workshop to share experiences in managing patients with GPP. Educational needs and clinical practice gaps grouped according to healthcare system level were discussed and ranked using interactive polling. Results: Lack of experience of GPP among HCPs was identified as an important individual HCP-level clinical practice gap. Limited understanding of the presentation and pathogenesis of GPP among non-specialists means misdiagnosis is common, delaying referral and treatment. In countries where patients may present to general practitioners or emergency department HCPs, GPP is often mistaken for an infection. Among dermatologists who can accurately diagnose GPP, limited knowledge of treatments may necessitate referral to a colleague with more experience in GPP. At the organisational level, important needs identified were educating emergency department HCPs to recognise GPP as an autoinflammatory disease and improving communication, cooperation and definitions of roles within multidisciplinary teams supporting patients with GPP. At the regulatory level, robust clinical trial data, clear and consistent treatment guidelines and approved therapies were identified as high priorities. Conclusions: The educational imperative most consistently identified across the participating countries is for HCPs to understand that GPP can be life-threatening if appropriate treatment initiation is delayed, and to recognise when to refer patients to a colleague with more experience of GPP management.

Original languageEnglish (US)
Pages (from-to)381-393
Number of pages13
JournalDermatology and Therapy
Issue number2
StatePublished - Feb 2022
Externally publishedYes


  • Clinical practice gap
  • Generalized pustular psoriasis
  • Global perspective
  • Unmet educational need

ASJC Scopus subject areas

  • Dermatology


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