Unilateral Shwartzman reaction

cortical necrosis in one kidney following in vivo perfusion with endotoxin

Leopoldo Raij, W. F. Keane, A. F. Michael

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 μg of endotoxin followed by the i.v. administration of 250 μg of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalKidney International
Volume12
Issue number2
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Shwartzman Phenomenon
Kidney Cortex Necrosis
Endotoxins
Necrosis
Perfusion
Kidney
Vascular Endothelium
Rabbits

ASJC Scopus subject areas

  • Nephrology

Cite this

Unilateral Shwartzman reaction : cortical necrosis in one kidney following in vivo perfusion with endotoxin. / Raij, Leopoldo; Keane, W. F.; Michael, A. F.

In: Kidney International, Vol. 12, No. 2, 01.12.1977, p. 91-95.

Research output: Contribution to journalArticle

Raij, Leopoldo ; Keane, W. F. ; Michael, A. F. / Unilateral Shwartzman reaction : cortical necrosis in one kidney following in vivo perfusion with endotoxin. In: Kidney International. 1977 ; Vol. 12, No. 2. pp. 91-95.
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