Unilateral Shwartzman reaction: cortical necrosis in one kidney following in vivo perfusion with endotoxin

L. Raij; W. F. Keane; A. F. Michael

doi:10.1038/ki.1977.85

Unilateral Shwartzman reaction: cortical necrosis in one kidney following in vivo perfusion with endotoxin

L. Raij, W. F. Keane, A. F. Michael

Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 μg of endotoxin followed by the i.v. administration of 250 μg of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.

Original language	English (US)
Pages (from-to)	91-95
Number of pages	5
Journal	Kidney international
Volume	12
Issue number	2
DOIs	https://doi.org/10.1038/ki.1977.85
State	Published - 1977

ASJC Scopus subject areas

Nephrology

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abstract = "Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 μg of endotoxin followed by the i.v. administration of 250 μg of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.",

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AU - Michael, A. F.

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AB - Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 μg of endotoxin followed by the i.v. administration of 250 μg of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.

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Unilateral Shwartzman reaction: cortical necrosis in one kidney following in vivo perfusion with endotoxin

Abstract

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