Unilateral Shwartzman reaction: cortical necrosis in one kidney following in vivo perfusion with endotoxin

L. Raij, W. F. Keane, A. F. Michael

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Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 μg of endotoxin followed by the i.v. administration of 250 μg of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalKidney international
Issue number2
StatePublished - Jan 1 1977


ASJC Scopus subject areas

  • Nephrology

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