Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

Sofía M. Muns; Mónica P. González; Victor M. Villegas; Gabriela De La Vega; Camila V. Ventura; Audina M. Berrocal

doi:10.1186/s40942-020-00240-1

Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

Sofía M. Muns, Mónica P. González, Victor M. Villegas, Gabriela De La Vega, Camila V. Ventura, Audina M. Berrocal

Research output: Contribution to journal › Article › peer-review

Abstract

Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.

Original language	English (US)
Article number	36
Journal	International Journal of Retina and Vitreous
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/s40942-020-00240-1
State	Published - Aug 1 2020
Externally published	Yes

Keywords

Coloboma
Excavated disc anomaly
Morning glory disc anomaly
Optic disc
Zika virus

ASJC Scopus subject areas

Ophthalmology

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10.1186/s40942-020-00240-1

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@article{9635eb3da6d4424ca283f9de1d59a25c,

title = "Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure",

abstract = "Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.",

keywords = "Coloboma, Excavated disc anomaly, Morning glory disc anomaly, Optic disc, Zika virus",

author = "Muns, {Sof{\'i}a M.} and Gonz{\'a}lez, {M{\'o}nica P.} and Villegas, {Victor M.} and {De La Vega}, Gabriela and Ventura, {Camila V.} and Berrocal, {Audina M.}",

note = "Funding Information: Supported in part by the National Eye Institute Center Core Grant (P30EY014801), and an unrestricted grant to the University of Miami from Research to Prevent Blindness, Inc. (New York, NY).",

year = "2020",

month = aug,

day = "1",

doi = "10.1186/s40942-020-00240-1",

language = "English (US)",

volume = "6",

journal = "International Journal of Retina and Vitreous",

issn = "2056-9920",

publisher = "BioMed Central Ltd.",

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T1 - Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

AU - Muns, Sofía M.

AU - González, Mónica P.

AU - Villegas, Victor M.

AU - De La Vega, Gabriela

AU - Ventura, Camila V.

AU - Berrocal, Audina M.

N1 - Funding Information: Supported in part by the National Eye Institute Center Core Grant (P30EY014801), and an unrestricted grant to the University of Miami from Research to Prevent Blindness, Inc. (New York, NY).

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.

AB - Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.

KW - Coloboma

KW - Excavated disc anomaly

KW - Morning glory disc anomaly

KW - Optic disc

KW - Zika virus

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