Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

Sofía M. Muns; Mónica P. González; Victor M. Villegas; Gabriela De La Vega; Camila V. Ventura; Audina M. Berrocal

doi:10.1186/s40942-020-00240-1

Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

Sofía M. Muns, Mónica P. González, Victor M. Villegas, Gabriela De La Vega, Camila V. Ventura, Audina M. Berrocal

Ophthalmology

Research output: Contribution to journal › Article

Abstract

Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.

Original language	English (US)
Article number	36
Journal	International Journal of Retina and Vitreous
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/s40942-020-00240-1
State	Published - Aug 1 2020

Keywords

Coloboma
Excavated disc anomaly
Morning glory disc anomaly
Optic disc
Zika virus

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1186/s40942-020-00240-1

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Muns, S. M., González, M. P., Villegas, V. M., De La Vega, G., Ventura, C. V., & Berrocal, A. M. (2020). Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure. International Journal of Retina and Vitreous, 6(1), [36]. https://doi.org/10.1186/s40942-020-00240-1

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abstract = "Background: To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure. Case presentation: A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis. Conclusions: This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.",

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AU - Muns, Sofía M.

AU - González, Mónica P.

AU - Villegas, Victor M.

AU - De La Vega, Gabriela

AU - Ventura, Camila V.

AU - Berrocal, Audina M.

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