Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia

Luis J. Borda, Joshua S. Mervis, Robert Kirsner

Research output: Contribution to journalArticle

Abstract

Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in that it shares features of both localized and generalized forms. Moreover, the temporal and spatial association with pyoderma gangrenosum is unique and may reflect a related inflammatory pathway.

Original languageEnglish (US)
JournalDermatology online journal
Volume25
Issue number3
StatePublished - Mar 15 2019

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Granuloma Annulare
Pyoderma Gangrenosum
B-Cell Chronic Lymphocytic Leukemia
Thigh
Leg Ulcer
Dyslipidemias
Amputation
Physical Examination
Leg
Knee
Histology
Extremities
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia. / Borda, Luis J.; Mervis, Joshua S.; Kirsner, Robert.

In: Dermatology online journal, Vol. 25, No. 3, 15.03.2019.

Research output: Contribution to journalArticle

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