Unfavorable Vascular Anatomy Is Associated with Increased Revascularization Time and Worse Outcome in Anterior Circulation Thrombectomy

Brian M. Snelling, Samir Sur, Sumedh S. Shah, Stephanie Chen, Simon A. Menaker, David J. McCarthy, Dileep R. Yavagal, Eric C. Peterson, Robert M. Starke

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Reperfusion time influences patient outcome in mechanical thrombectomy for large vessel occlusion. We analyzed anatomic features that could be used to make preoperative and intraoperative decisions to minimize revascularization time. Methods: We reviewed a prospectively maintained database for patients with stroke evaluated from February 2015 to July 2016. Patients received a score based on bovine arch, aortic arch, and internal carotid artery dolichoarteriopathy (B.A.D. score), which we correlated with procedural times and outcomes. Univariate analysis was performed to identify predictors of procedural times, revascularization, complications, and outcome. Relevant variables were assessed via multivariate regression. Results: We identified 61 patients (31 men) who underwent transfemoral thrombectomy. Mean puncture to reperfusion time was 46 minutes. Age >75 years (odds ratio [OR] = 3.98; 95% confidence interval [CI], 1.17–13.54; P = 0.027) and high B.A.D. score (OR = 2.55; 95% CI, 1.17–5.57; P = 0.019) were significant predictors of puncture to reperfusion time >40 minutes. Mean puncture to first-pass time was 24 ± 14.2 minutes. Age >65 years (OR = 4.68; 95% CI, 1.07–20.55; P = 0.041) and high B.A.D. score (OR = 2.84; 95% CI, 1.18–6.85; P = 0.020) were independently predictive of time to first pass >20 minutes. Lower scores predicted higher Thrombolysis In Cerebral Infarction score (OR = 0.07; 95% CI, 0.01–0.81; P = 0.033). Higher scores predicted hemorrhagic transformation (OR = 4.8; 95% CI, 1.19–12.29; P = 0.024) and modified Rankin Scale score >4 (OR = 3.0; 95% CI, 1.15–7.92; P = 0.025) after thrombectomy. Conclusions: Bovine variation, aortic arch type, and internal carotid artery dolichoarteriopathy are associated with increased revascularization time and poor outcomes in thrombectomy. We developed the B.A.D. score to predict reperfusion time and outcomes, demonstrating need for preoperative anatomic evaluation to guide treatment.

Original languageEnglish (US)
Pages (from-to)e976-e983
JournalWorld neurosurgery
Volume120
DOIs
StatePublished - Dec 2018

Keywords

  • Bovine
  • Ischemia
  • Large vessel
  • Occlusion
  • Outcomes research
  • Stroke
  • Thrombectomy
  • Tortuosity

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Snelling, B. M., Sur, S., Shah, S. S., Chen, S., Menaker, S. A., McCarthy, D. J., Yavagal, D. R., Peterson, E. C., & Starke, R. M. (2018). Unfavorable Vascular Anatomy Is Associated with Increased Revascularization Time and Worse Outcome in Anterior Circulation Thrombectomy. World neurosurgery, 120, e976-e983. https://doi.org/10.1016/j.wneu.2018.08.207