Unexpected diminished innervation of epidermis and dermoepidermal junction in lichen amyloidosus

B. Maddison, M. R. Namazi, L. S. Samuel, J. Sanchez, R. Pichardo, J. Stocks, D. Maruziva, Gil Yosipovitch

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Lichen amyloidosus is a localized, chronic, pruritic skin disease characterized by deposition of amyloid in the papillary dermis. The pathogenesis of the pruritus of lichen amyloidosus is largely unknown. Objectives: To determine any change in the nerve fibre density in lichen amyloidosus lesions as an explanation for itch. Methods: Using an antibody to protein gene product (PGP) 9.5, the immunohistochemical analysis of the skin biopsies of 30 Hispanic patients with clinicopathologically proven lichen amyloidosus and of 11 healthy Hispanic controls matched for age, sex and site was performed. Results: Unexpectedly, the mean amount of PGP9.5 stain, a measure for nerve fibre amount, for the healthy controls was higher than the lichen amyloidosus group both in the epidermis (P < 0.0019) and dermoepidermal junction (P < 0.0064). No change was observed in the papillary dermis. Furthermore, the proportion of area covered by PGP9.5 showed a significant decrease in the epidermis (P < 0.0024) and dermoepidermal junction (P < 0.0075) in lichen amyloidosus compared with healthy controls. Age, gender and body site were found not to be influencing factors in nerve fibre amounts in lichen amyloidosus samples. Conclusions: We speculate that the severe pruritus observed in lichen amyloidosus might be the result of the hypersensitivity of the remaining nerve fibres as a response to an unexplained neurodegeneration of the absent nerve fibres.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalBritish Journal of Dermatology
Volume159
Issue number2
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Fingerprint

Lichens
Epidermis
Nerve Fibers
Pruritus
Dermis
Hispanic Americans
Skin Diseases
Amyloid
Hypersensitivity
Coloring Agents
Biopsy
Skin
Antibodies

Keywords

  • Lichen amyloidosus
  • Nerve fibre density
  • Pruritus
  • Skin innervation

ASJC Scopus subject areas

  • Dermatology

Cite this

Unexpected diminished innervation of epidermis and dermoepidermal junction in lichen amyloidosus. / Maddison, B.; Namazi, M. R.; Samuel, L. S.; Sanchez, J.; Pichardo, R.; Stocks, J.; Maruziva, D.; Yosipovitch, Gil.

In: British Journal of Dermatology, Vol. 159, No. 2, 01.08.2008, p. 403-406.

Research output: Contribution to journalArticle

Maddison, B. ; Namazi, M. R. ; Samuel, L. S. ; Sanchez, J. ; Pichardo, R. ; Stocks, J. ; Maruziva, D. ; Yosipovitch, Gil. / Unexpected diminished innervation of epidermis and dermoepidermal junction in lichen amyloidosus. In: British Journal of Dermatology. 2008 ; Vol. 159, No. 2. pp. 403-406.
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abstract = "Background: Lichen amyloidosus is a localized, chronic, pruritic skin disease characterized by deposition of amyloid in the papillary dermis. The pathogenesis of the pruritus of lichen amyloidosus is largely unknown. Objectives: To determine any change in the nerve fibre density in lichen amyloidosus lesions as an explanation for itch. Methods: Using an antibody to protein gene product (PGP) 9.5, the immunohistochemical analysis of the skin biopsies of 30 Hispanic patients with clinicopathologically proven lichen amyloidosus and of 11 healthy Hispanic controls matched for age, sex and site was performed. Results: Unexpectedly, the mean amount of PGP9.5 stain, a measure for nerve fibre amount, for the healthy controls was higher than the lichen amyloidosus group both in the epidermis (P < 0.0019) and dermoepidermal junction (P < 0.0064). No change was observed in the papillary dermis. Furthermore, the proportion of area covered by PGP9.5 showed a significant decrease in the epidermis (P < 0.0024) and dermoepidermal junction (P < 0.0075) in lichen amyloidosus compared with healthy controls. Age, gender and body site were found not to be influencing factors in nerve fibre amounts in lichen amyloidosus samples. Conclusions: We speculate that the severe pruritus observed in lichen amyloidosus might be the result of the hypersensitivity of the remaining nerve fibres as a response to an unexplained neurodegeneration of the absent nerve fibres.",
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