Understanding the Intersection of Young Age, Mucosal Injury, and HIV Susceptibility

Kristen A. Porter, Jim Turpin, Lisa Begg, Gina Brown, Nahida Chakhtoura, Elizabeth Church, Cynthia Grossman, Charles Wira, Fulvia Veronese

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Adolescent boys and girls are disproportionately affected in the current HIV epidemic. Numerous sociobehavioral studies have addressed the indirect drivers surrounding this vulnerability - for example, socioeconomic, geographical locale, and all forms of violence. However, the direct factors that may influence infection, such as the anatomical and physiological maturation of the anogenital tracts of adolescents or the trauma and wound-healing processes of injured mucosal tissue, are understudied and represent a gap within the HIV prevention field. This article reviews the epidemiology of HIV infection and violence in adolescents and the available basic science knowledge attending this research area. More importantly, this review highlights the most critical gaps that need to be addressed to design preventive interventions that are safe and effective for this population, which is key to ending the HIV pandemic. Copyright Mary Ann Liebert, Inc 2016.

Original languageEnglish (US)
Pages (from-to)1149-1158
Number of pages10
JournalAIDS research and human retroviruses
Issue number10-11
StatePublished - Nov 1 2016


  • HIV
  • HIV prevention
  • HIV transmission
  • HIV/AIDS pathogenesis
  • mucosal

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases


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