Understanding modes of moderate sedation during gastrointestinal procedures

a current review of the literature

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Recommendations for routine screening for colorectal cancer with colonoscopy are likely to substantially increase the demand for provision of sedation for these procedures. Because of this burgeoning caseload and associated economic constraints, it is unlikely that anesthesiologists will be available for all such procedures, particularly those involving average-risk patients. Thus, sedative agents that can be safely administered by nonanesthesiologists, appropriately trained in monitoring and managing the patient's airway, are desperately needed. New concepts in sedation for colonoscopy include enhanced mechanisms for drug delivery such as patient-controlled sedation/analgesia and target-controlled infusion, along with the development of new drugs such as a modified cyclodextrin-based formulation of propofol and fospropofol disodium (Aquavan Injection), a water-soluble prodrug of propofol.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalJournal of Clinical Anesthesia
Volume19
Issue number5
DOIs
StatePublished - Aug 1 2007

Fingerprint

Conscious Sedation
Propofol
Colonoscopy
Patient-Controlled Analgesia
Prodrugs
Cyclodextrins
Physiologic Monitoring
Hypnotics and Sedatives
Pharmaceutical Preparations
Colorectal Neoplasms
Economics
Injections
Water
fospropofol
Anesthesiologists

Keywords

  • Colonoscopy
  • Endoscopy
  • Fospropofol disodium
  • Propofol
  • Rapid recovery
  • Sedation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

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abstract = "Recommendations for routine screening for colorectal cancer with colonoscopy are likely to substantially increase the demand for provision of sedation for these procedures. Because of this burgeoning caseload and associated economic constraints, it is unlikely that anesthesiologists will be available for all such procedures, particularly those involving average-risk patients. Thus, sedative agents that can be safely administered by nonanesthesiologists, appropriately trained in monitoring and managing the patient's airway, are desperately needed. New concepts in sedation for colonoscopy include enhanced mechanisms for drug delivery such as patient-controlled sedation/analgesia and target-controlled infusion, along with the development of new drugs such as a modified cyclodextrin-based formulation of propofol and fospropofol disodium (Aquavan Injection), a water-soluble prodrug of propofol.",
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