Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection

David O'Connor, Thomas Friedrich, Austin Hughes, Todd M. Allen, David Watkins

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Infection of rhesus macaques with simian immunodeficiency virus (SIV) is an excellent model system for studying viral adaptation to immune responses. In this review, we discuss how the SIV-infected macaque has provided unequivocal evidence for cytotoxic T-lymphocyte (CTL) selection of viral escape variants. This improved understanding of CTL escape may influence human immunodeficiency virus (HIV) vaccine design as well as our understanding of HIV pathogenesis.

Original languageEnglish (US)
Pages (from-to)115-126
Number of pages12
JournalImmunological reviews
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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