Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection

David O'Connor, Thomas Friedrich, Austin Hughes, Todd M. Allen, David Watkins

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Infection of rhesus macaques with simian immunodeficiency virus (SIV) is an excellent model system for studying viral adaptation to immune responses. In this review, we discuss how the SIV-infected macaque has provided unequivocal evidence for cytotoxic T-lymphocyte (CTL) selection of viral escape variants. This improved understanding of CTL escape may influence human immunodeficiency virus (HIV) vaccine design as well as our understanding of HIV pathogenesis.

Original languageEnglish
Pages (from-to)115-126
Number of pages12
JournalImmunological Reviews
Volume183
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

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Simian Immunodeficiency Virus
Cytotoxic T-Lymphocytes
Virus Diseases
HIV
Macaca
Macaca mulatta
Vaccines
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection. / O'Connor, David; Friedrich, Thomas; Hughes, Austin; Allen, Todd M.; Watkins, David.

In: Immunological Reviews, Vol. 183, 01.12.2001, p. 115-126.

Research output: Contribution to journalArticle

O'Connor, David ; Friedrich, Thomas ; Hughes, Austin ; Allen, Todd M. ; Watkins, David. / Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection. In: Immunological Reviews. 2001 ; Vol. 183. pp. 115-126.
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