Understanding animal models of elite control: Windows on effective immune responses against immunodeficiency viruses

Philip A. Mudd, David I. Watkins

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Purpose of review: We will summarize recent advances in research regarding control of simian immunodeficiency virus replication in nonhuman primate models. We will then relate these findings to the broader field of human immunodeficiency virus (HIV) vaccine development. Recent findings: Recent studies have highlighted the importance of T-cell responses in elite control, especially CD8 T-cell responses and provide insight into the kinetics and qualities of such effective responses. Additionally, these findings suggest that the peptides bound by elite control-associated major histocompatibility complex class I molecules in monkeys and humans share many properties. Summary: Animal models of effective immune control of immunodeficiency virus replication have provided important insight into the components of successful immune responses against these viruses. Similarities between the human and nonhuman primate responses to immunodeficiency viruses should help us understand the nature of elite control. Further study of the acute phase, in which virus replication is first brought under control, may help define important characteristics of viral control that could be engendered by a successful HIV vaccine.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalCurrent Opinion in HIV and AIDS
Issue number3
StatePublished - May 2011
Externally publishedYes


  • animal model
  • CD8 T cell
  • elite control
  • immune control

ASJC Scopus subject areas

  • Hematology
  • Oncology(nursing)
  • Immunology
  • Infectious Diseases
  • Virology
  • Oncology


Dive into the research topics of 'Understanding animal models of elite control: Windows on effective immune responses against immunodeficiency viruses'. Together they form a unique fingerprint.

Cite this