Understanding and Treating Pruritus in Primary Biliary Cholangitis

Andres F. Carrion, Jordan D. Rosen, Cynthia Levy

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Pruritus is a common symptom with primary biliary cholangitis. Research has focused on refining understanding of the neurohumoral pathways involved in transduction of pruritus from peripheral cutaneous receptors to the central nervous system, and identifying modulating drugs. Current treatments have variable efficacy and safety. Because of the deleterious effects on quality of life or debilitation, many patients necessitate individualized therapeutic approaches; clinicians may need to consider invasive treatment options. This article highlights various therapeutic interventions, from general measures to invasive strategies, and novel agents under investigation, providing clinicians with the management tricks of the trade.

Original languageEnglish (US)
JournalClinics in Liver Disease
StateAccepted/In press - Jan 1 2018


  • Cholestasis
  • Intractable
  • Itch
  • Refractory
  • Therapy

ASJC Scopus subject areas

  • Hepatology


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