Undernutrition as a major contributing factor in the pathogenesis of bronchopulmonary dysplasia

L. Frank, Ilene Sosenko

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The protean effects of undernutrition on lung defenses and repair capabilities suggest that less than adequate nutritional support is a key pathogenetic factor in the development of bronchopulmonary dysplasia (BDP). Very-low-birthweight (VLBW, ≤ 1,000 g) premature infants who require intensive respiratory support have a distressingly high incidence of chronic lung disease or BPD. Many VLBW infants are currently undernourished during the most acute phase of their respiratory illness. Because VLBW newborns have only meager caloric reserves (fat, glycogen), and have only marginally sufficient stores of nutrients needed for effective lung defenses and repair capacity (vitamins A and E, copper, zinc, iron, selenium, essential fatty acids, etc.), the adequacy of nutritional support provided them will almost certainly influence their ability to tolerate early stress, and it may play a critical role in their clinical outcome. Experimental studies, combined with a limited number of clinical studies, clearly demonstrate that undernutrition can interact with each of the other well-accepted etiologic factors involved in the pathogenesis of BPD. Nutritional status affects the lung's ability to resist hyperoxic damage, to replace damaged/sloughed lung cells caused by barotrauma, to promote continued lung growth, to resist infection, and to tolerate prolonged and potentially toxic stresses in general. By providing more ideal nutritional support, clinicians may be able to apply preventive treatment to influence the outcome of intensive respiratory therapy in the VLBW newborn.

Original languageEnglish
Pages (from-to)725-729
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume138
Issue number3
StatePublished - Jan 1 1988

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Bronchopulmonary Dysplasia
Malnutrition
Nutritional Support
Lung
Newborn Infant
Barotrauma
Respiratory Therapy
Essential Fatty Acids
Poisons
Selenium
Nutritional Status
Vitamin A
Vitamin E
Glycogen
Premature Infants
Lung Diseases
Zinc
Copper
Chronic Disease
Iron

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Undernutrition as a major contributing factor in the pathogenesis of bronchopulmonary dysplasia. / Frank, L.; Sosenko, Ilene.

In: American Review of Respiratory Disease, Vol. 138, No. 3, 01.01.1988, p. 725-729.

Research output: Contribution to journalArticle

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