Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats

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Abstract

We assessed local cere-bral glucose metabolism (lCMRGic) and blood flow (1CBF) interrelationships in the first hour after parasagittal fluidpercussion head injury (FPI) in rats. Matched series were studied autoradiographically for lCMRGic and 1CBF with 2-[14C]deoxyglucose and 14C-labeled iodoantipyrine, respectively. Three-dimensional autoradiographic-image mapping was used to generate average data sets from which a mean ICMRcic-to-lCBF ratio data set was derived. 1CBF in neocortical regions ipsilateral to the trauma were depressed, on average, by 44% compared with sham-FPI rats, whereas contralateral 1CBF values were not altered. By contrast, ICMRcic was elevated in many cortical and subcortical sites of both hemispheres; this amounted to 1.3- to 1.4-fold increases in neocortical regions in the thalamus and 1.6- to 1.7-fold increases in the hippocampus. The ICMRcic-to-lCBF ratio data revealed striking elevations both ipsilateral (P = 7 X 10~7) and contralateral to the FPI (P = 0.003). The extent of metabolism-flow uncoupling, on average, amounted to 2.5fold in the ipsilateral hippocampus and neocortex and 1.7-fold contralaterally. The loci of pronounced metabolism-flow dissociation corresponded closely to the previously documented histological distribution of neuronal necrosis. Our findings resemble events occurring in the acute focal ischémie penumbra and suggest that similar injury mechanisms may be operative. head injury; glycolysis; coupling; autoradiography; image processing

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume41
Issue number6
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Physiology

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