Unconventional secretion of tubby and tubby-like protein 1

Nora B. Caberoy, Wei Li

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Tubby-like proteins (Tulps) with no signal peptide have been characterized as cytoplasmic proteins with various intracellular functions, including binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2]. PI(4,5)P2 has been implicated in unconventional secretion of fibroblast growth factor-2 without a signal peptide. Here, we show that all Tulps are expressed intracellularly and extracellularly. Tubby secretion is partially dependent on its PI(4,5)P2-binding activity with an essential secretory signal in the N-terminus. Pathogenic mutation in Tubby mice has no impact on tubby extracellular trafficking. Moreover, unconventional secretion of tubby and Tulp1 is independent of endoplasmic reticulum-Golgi pathway. These data implicate that Tulps may function extracellularly as well.

Original languageEnglish (US)
Pages (from-to)3057-3062
Number of pages6
JournalFEBS letters
Volume583
Issue number18
DOIs
StatePublished - Sep 17 2009

Keywords

  • Extracellular trafficking
  • Obesity
  • Retinal degeneration
  • Tubby
  • Tubby-like protein 1
  • Unconventional secretion

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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