Unaltered plasma GH levels in acromegalics and normal men and women after administration of [Pyro]Glu-Ser-Gly-NH2, a proposed GH-releasing hormone

David Gonzalez-Barcena, Abba J. Kastin, David H. Coy, Seymour Glick, Don S. Schalch, Louyse A. Lee, J. Pedro Arzac, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

[pyro]Glu Ser Gly NH 2 has been reported to release growth hormone (GH). Therefore, this tripeptide was injected iv at a dose of 600 μg into 10 men and women, 3 of whom had acromegaly. Plasma levels of GH, thyroid stimulating hormone, luteinizing hormone and follicle stimulating hormone were measured, but no consistent elevations were found. The results do not support the proposal that [pyro]Glu Ser Gly NH 2 is the GH releasing hormone.

Original languageEnglish (US)
Pages (from-to)1134-1136
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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