Seventeen surgical biopsy specimens from Ugandan patients with liver cell carcinoma were studied by electron microscopy. The ultrastructural features observed in this series are similar to those previously reported by others. A narrow range in the degree of differentiation of tumor cells is noted, but in most cases they are easily recognizable as of hepatic origin. No morphologic correlation with a-feto-protein in the serum or with Australia antigen was found and no virus particles were seen in the material examined. Despite the absence of significant new findings in this survey, it is suggested that electron microscopic studies in liver cancer should be pursued, but more specifically directed toward the investigation of in vitro cultures and the search for virus therein. Application of special techniques for localization of fetal protein production might also provide new information on the relationship of this antigen to other functions of the hepatic cell during tumorigenesis and following therapy.
ASJC Scopus subject areas
- Cancer Research