Abstract
Because methionine sulfoximine (MSO), unlike most convulsant drugs, has a long latent period, it can be used to study changes in the brain before the occurrence of seizures. A previous light microscopic study during the preictal period following MSO revealed the development of an Alzheimer type II astrocyte change as the principal morphologic alteration. This ultrastructural study of the brain cortex was performed in rats during the preictal period following MSO administration. The morphologic changes were restricted to the astrocytes and consisted of cytoplasmic enlargement, mitochondrial and rough endoplasmic reticulum proliferation, accumulation of glycogen, development of cisternal and saccular smooth endoplasmic reticulum, nuclear chromatin clumping, and hydropic degenerative changes. These findings resemble those seen in experimental ammonia encephalopathy, suggesting an important role of ammonia in the evolution of the morphologic changes described. The findings, moreover, suggest that the primary effect of MSO is on astrocytes and that astrocytic abnormalities play a role in the development of MSO-induced seizures.
| Original language | English |
|---|---|
| Pages (from-to) | 285-300 |
| Number of pages | 16 |
| Journal | American Journal of Pathology |
| Volume | 86 |
| Issue number | 2 |
| State | Published - Dec 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Ultrastructural study of methionine sulfoximine induced Alzheimer type II astrocytosis. / Gutierrez, J. A.; Norenberg, Michael D.
In: American Journal of Pathology, Vol. 86, No. 2, 01.12.1977, p. 285-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultrastructural study of methionine sulfoximine induced Alzheimer type II astrocytosis
AU - Gutierrez, J. A.
AU - Norenberg, Michael D
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Because methionine sulfoximine (MSO), unlike most convulsant drugs, has a long latent period, it can be used to study changes in the brain before the occurrence of seizures. A previous light microscopic study during the preictal period following MSO revealed the development of an Alzheimer type II astrocyte change as the principal morphologic alteration. This ultrastructural study of the brain cortex was performed in rats during the preictal period following MSO administration. The morphologic changes were restricted to the astrocytes and consisted of cytoplasmic enlargement, mitochondrial and rough endoplasmic reticulum proliferation, accumulation of glycogen, development of cisternal and saccular smooth endoplasmic reticulum, nuclear chromatin clumping, and hydropic degenerative changes. These findings resemble those seen in experimental ammonia encephalopathy, suggesting an important role of ammonia in the evolution of the morphologic changes described. The findings, moreover, suggest that the primary effect of MSO is on astrocytes and that astrocytic abnormalities play a role in the development of MSO-induced seizures.
AB - Because methionine sulfoximine (MSO), unlike most convulsant drugs, has a long latent period, it can be used to study changes in the brain before the occurrence of seizures. A previous light microscopic study during the preictal period following MSO revealed the development of an Alzheimer type II astrocyte change as the principal morphologic alteration. This ultrastructural study of the brain cortex was performed in rats during the preictal period following MSO administration. The morphologic changes were restricted to the astrocytes and consisted of cytoplasmic enlargement, mitochondrial and rough endoplasmic reticulum proliferation, accumulation of glycogen, development of cisternal and saccular smooth endoplasmic reticulum, nuclear chromatin clumping, and hydropic degenerative changes. These findings resemble those seen in experimental ammonia encephalopathy, suggesting an important role of ammonia in the evolution of the morphologic changes described. The findings, moreover, suggest that the primary effect of MSO is on astrocytes and that astrocytic abnormalities play a role in the development of MSO-induced seizures.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017579115&partnerID=8YFLogxK
M3 - Article
C2 - 556886
AN - SCOPUS:0017579115
VL - 86
SP - 285
EP - 300
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 2
ER -