Ultrastructural studies of olivopontocerebellar atrophy

Carol K. Petito, Michael N. Hart, Major, Robert S. Porro, Kenneth M. Earle

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Three cases of olivopontocerebellar atrophy, one of which included a cerebellar biopsy, were examined for ultrastructural changes. Degenerative changes were identified within the afferent cerebellar fibers and within the cerebellar neurons, especially the Purkinje cells. Although the majority of the degenerative alterations have been previously described in a variety of disease states, there were some findings that have not been previously reported, including unusual striped bodies and Lafora body inclusions within Purkinje dendrites. The relationship between OPCA and other diseases is discussed and a possible slow viral etiology is considered.

Original languageEnglish (US)
Pages (from-to)503-522
Number of pages20
JournalJournal of Neuropathology and Experimental Neurology
Volume32
Issue number4
DOIs
StatePublished - Oct 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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