Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births

Kanjaksha Ghosh, Dileep R Yavagal, Callista Phillips, Farah Jijina, A. V. Pathare, Lily Kerketta, Y. S. Iyer, C. N. Nair, S. Shinde, Dipika Mohanty

Research output: Contribution to journalArticle

Abstract

A 28 year old female patient presented with refractory anaemia since childhood and recurrent still-births at 28-30 weeks of gestation. One still-born child was hydropic at birth. Bone marrow showed characteristic morphological changes of congenital dyserythropoietic anaemia (CDA)-Type III. Electron microscopy showed disruption of the nuclear membrane, spongy appearance of nuclei, stacks of microtubules in intermediate normoblasts and myelin figures in erythroid cells. In vitro culture and karyotype data from the bone marrow of the patient is presented. Recurrent still-births in association with congenital dyserythropoietic anaemia has rarely been reported in the literature.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalHaematologia
Volume29
Issue number1
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Congenital Dyserythropoietic Anemia
Karyotype
Cell Culture Techniques
Bone Marrow
Parturition
Refractory Anemia
Erythroblasts
Erythroid Cells
Nuclear Envelope
Myelin Sheath
Microtubules
Edema
Electron Microscopy
Pregnancy

Keywords

  • BFU-E
  • Dyserythropoiesis
  • Gigantoblasts
  • Hyperploidy
  • Microtubules

ASJC Scopus subject areas

  • Hematology

Cite this

Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births. / Ghosh, Kanjaksha; Yavagal, Dileep R; Phillips, Callista; Jijina, Farah; Pathare, A. V.; Kerketta, Lily; Iyer, Y. S.; Nair, C. N.; Shinde, S.; Mohanty, Dipika.

In: Haematologia, Vol. 29, No. 1, 01.12.1998, p. 41-45.

Research output: Contribution to journalArticle

Ghosh, K, Yavagal, DR, Phillips, C, Jijina, F, Pathare, AV, Kerketta, L, Iyer, YS, Nair, CN, Shinde, S & Mohanty, D 1998, 'Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births', Haematologia, vol. 29, no. 1, pp. 41-45.
Ghosh, Kanjaksha ; Yavagal, Dileep R ; Phillips, Callista ; Jijina, Farah ; Pathare, A. V. ; Kerketta, Lily ; Iyer, Y. S. ; Nair, C. N. ; Shinde, S. ; Mohanty, Dipika. / Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births. In: Haematologia. 1998 ; Vol. 29, No. 1. pp. 41-45.
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