Ulcers caused by bullous morphea treated with tissue-engineered skin

Lucy K. Martin, Robert S. Kirsner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Bullous morphea is an uncommon form of localized scleroderma. The exact pathogenesis is unknown and treatment of the accompanying ulcers is problematic. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with the tissue-engineered skin Apligraf (Organogenesis Inc., Canton, MA). The patient experienced rapid improvement in granulation tissue and the ulcers healed 4 months after a single application. The rationale for the use of Apligraf is based on experience with patients with venous ulcers who have surrounding peri-ulcer fibrosis. This condition, termed lipodermatosclerosis, has been reported as a poor prognostic factor for healing, yet many ulcers associated with lipodermatosclerosis may respond to treatment with tissue-engineered skin. Taken in concert, these results suggest a role for tissue-engineered skin in the treatment of chronic wounds with surrounding fibrosis.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
JournalInternational journal of dermatology
Issue number5
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Dermatology


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