TY - JOUR
T1 - Ulcers caused by bullous morphea treated with tissue-engineered skin
AU - Martin, Lucy K.
AU - Kirsner, Robert S.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Bullous morphea is an uncommon form of localized scleroderma. The exact pathogenesis is unknown and treatment of the accompanying ulcers is problematic. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with the tissue-engineered skin Apligraf (Organogenesis Inc., Canton, MA). The patient experienced rapid improvement in granulation tissue and the ulcers healed 4 months after a single application. The rationale for the use of Apligraf is based on experience with patients with venous ulcers who have surrounding peri-ulcer fibrosis. This condition, termed lipodermatosclerosis, has been reported as a poor prognostic factor for healing, yet many ulcers associated with lipodermatosclerosis may respond to treatment with tissue-engineered skin. Taken in concert, these results suggest a role for tissue-engineered skin in the treatment of chronic wounds with surrounding fibrosis.
AB - Bullous morphea is an uncommon form of localized scleroderma. The exact pathogenesis is unknown and treatment of the accompanying ulcers is problematic. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with the tissue-engineered skin Apligraf (Organogenesis Inc., Canton, MA). The patient experienced rapid improvement in granulation tissue and the ulcers healed 4 months after a single application. The rationale for the use of Apligraf is based on experience with patients with venous ulcers who have surrounding peri-ulcer fibrosis. This condition, termed lipodermatosclerosis, has been reported as a poor prognostic factor for healing, yet many ulcers associated with lipodermatosclerosis may respond to treatment with tissue-engineered skin. Taken in concert, these results suggest a role for tissue-engineered skin in the treatment of chronic wounds with surrounding fibrosis.
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U2 - 10.1046/j.1365-4362.2003.01763.x
DO - 10.1046/j.1365-4362.2003.01763.x
M3 - Article
C2 - 12755984
AN - SCOPUS:0038543059
VL - 42
SP - 402
EP - 404
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 5
ER -