An eclectic theory of ulcer etiopathogenesis is presented. Its objective is to give a rational explanation to most of the disturbances and changes occurring in ulcer patients. The theory highlights the intricate cellular mechanisms which keep the balance between acid aggression and mucosal defense. The new theory presented here will serve as the skeletal framework upon which new biomedical and biopsychosocial developments can be added to improve and expand the scientific explanation of why and how ulcers are formed.
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