Type III export: New uses for an old pathway

G. V. Plano, J. B. Day, F. Ferracci

Research output: Contribution to journalShort surveypeer-review

91 Scopus citations

Abstract

Gram-negative bacteria use type III secretion (TTS) systems to translocate proteins into the extracellular environment or directly into eukaryotic cells. These complex secretory systems are assembled from over 20 different structural proteins, including 10 that have counterparts in the flagellar export pathway. Secretion substrates are directed to the TTS machinery via mRNA and/or amino acid secretion signals. TTS chaperones bind to select secretion substrates and assist in the export process. Recent progress in the understanding of TTS is reviewed.

Original languageEnglish (US)
Pages (from-to)284-293
Number of pages10
JournalMolecular Microbiology
Volume40
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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