Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers

Yulia Gray, Nicholas Bruno, Evangelos V Badiavas, Caroline S. Wilkel

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cryoglobulins (CGs) are serum proteins that reversibly precipitate when the serum is cooled below 37°C. Cryoglobulinemias are associated with a variety of diseases, including hematologic, autoimmune, and infectious. Isolation of CGs requires handling the specimen with extreme care. We describe a 70-year-old man, recently diagnosed with chronic lymphocytic leukemia, who developed hemorrhagic crusted skin ulcers on his legs that were pruritic and painful. Results of skin biopsies showed dilated superficial, mid-dermal and deep-dermal blood vessels containing pink amorphous material and red blood cells. Cryoglobulinemia was suspected; however, an initial search for CGs was negative. There was concern about suboptimal handling of the specimen, and the test was repeated. Two percent CGs with IgM κ specificity were detected. This case illustrates the importance of the proper handling of specimens for evaluation of cryoglobulinemia.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalCutis
Volume70
Issue number6
StatePublished - Dec 1 2002
Externally publishedYes

Fingerprint

Cryoglobulins
Cryoglobulinemia
Leg Ulcer
Specimen Handling
Skin
Skin Ulcer
Hematologic Diseases
B-Cell Chronic Lymphocytic Leukemia
Immunoglobulin M
Blood Vessels
Blood Proteins
Leg
Erythrocytes
Biopsy
Serum

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Gray, Y., Bruno, N., Badiavas, E. V., & Wilkel, C. S. (2002). Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers. Cutis, 70(6), 319-323.

Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers. / Gray, Yulia; Bruno, Nicholas; Badiavas, Evangelos V; Wilkel, Caroline S.

In: Cutis, Vol. 70, No. 6, 01.12.2002, p. 319-323.

Research output: Contribution to journalArticle

Gray, Y, Bruno, N, Badiavas, EV & Wilkel, CS 2002, 'Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers', Cutis, vol. 70, no. 6, pp. 319-323.
Gray, Yulia ; Bruno, Nicholas ; Badiavas, Evangelos V ; Wilkel, Caroline S. / Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers. In: Cutis. 2002 ; Vol. 70, No. 6. pp. 319-323.
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