Type 2 Diabetes: Is Pancreas Transplantation an Option?

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13 Scopus citations

Abstract

Transplantation of the whole vascularized pancreas can provide insulin secretion in patients with insulin-dependent, type 1 diabetes mellitus (T1D). It restores euglycemia in most patients, with the potential to impact the chronic diabetic complications and quality of life. Pancreas transplantation (PT) is presently controversial for type 2 diabetes mellitus (T2D). For those patients with severe glycemic dysregulation, T2D can be associated with the same life-threatening sequelae as T1D such as severe hypoglycemia and kidney failure that could be corrected by pancreas (and kidney) transplantation. Thus, clinical indications and patient selection criteria are very important. This chapter will review the current status of PT for T2D and discuss the options and evolution of transplant perspectives.

Original languageEnglish (US)
Article number542
JournalCurrent Diabetes Reports
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • C-peptide
  • Pancreas transplantation
  • Patient candidates
  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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