Type 2 diabetes and coronary artery disease: Preserved ejection fraction and sudden cardiac death

M. Juhani Junttila, Antti M. Kiviniemi, E. Samuli Lepojärvi, Mikko Tulppo, Olli Pekka Piira, Tuomas Kenttä, Juha S. Perkiömäki, Olavi H. Ukkola, Robert J Myerburg, Heikki V. Huikuri

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Previous studies have shown that type 2 diabetes (DM2) is associated with sudden cardiac death (SCD) risk in post–myocardial infarction patients. The treatment of coronary artery disease (CAD) as well as DM2 has changed over time. Objective: The purpose of this study was to compare the incidence of SCD in DM2 and nondiabetic patients with CAD and preserved ejection fraction (EF) in a prospective observational study (ARTEMIS study). Methods: In 834 DM2 patients and 1112 nondiabetic patients with CAD enrolled, the EF measured ≥3 months after qualifying was 63% ± 10% in DM2 patients and 65% ± 8% in nondiabetic patients (P <.01). The primary end point was SCD or resuscitation from sudden cardiac arrest (SCA). All-cause mortality, cardiac mortality, non-SCD, hospitalization for heart failure, and acute coronary syndrome were secondary end points. Results: During a mean follow-up of 6.3 ± 1.6 years, SCDs/SCAs occurred in 50 patients. The prevalence of SCD/SCA was higher in DM2 patients (4.1%) than in nondiabetic patients (1.4%) (adjusted hazard ratio 2.6; 95% confidence interval 1.3–5.3; P <.01). However, the non-SCD component of cardiac mortality was not significantly different between DM2 and nondiabetic patients. In addition, heart failure hospitalizations were more common in DM2 patients (8.4%) than in nondiabetic patients (2.9%) (P <.001). The annual cardiac mortality in nondiabetic patients with CAD was 0.50%, which was lower than the 0.59% reported in the general Finnish population. Conclusion: DM2 is an independent risk factor for SCD/SCA in CAD patients with preserved EF. Cardiac mortality in nondiabetic CAD patients is slightly lower than that in the general population in the present treatment era.

Original languageEnglish (US)
Pages (from-to)1450-1456
Number of pages7
JournalHeart Rhythm
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2018

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Sudden Cardiac Death
Type 2 Diabetes Mellitus
Coronary Artery Disease
Mortality
Hospitalization
Heart Failure
Acute Coronary Syndrome
Resuscitation
Infarction
Population
Observational Studies

Keywords

  • Cardiac death
  • Coronary artery disease
  • Outcome
  • Sudden cardiac death
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Junttila, M. J., Kiviniemi, A. M., Lepojärvi, E. S., Tulppo, M., Piira, O. P., Kenttä, T., ... Huikuri, H. V. (2018). Type 2 diabetes and coronary artery disease: Preserved ejection fraction and sudden cardiac death. Heart Rhythm, 15(10), 1450-1456. https://doi.org/10.1016/j.hrthm.2018.06.017

Type 2 diabetes and coronary artery disease : Preserved ejection fraction and sudden cardiac death. / Junttila, M. Juhani; Kiviniemi, Antti M.; Lepojärvi, E. Samuli; Tulppo, Mikko; Piira, Olli Pekka; Kenttä, Tuomas; Perkiömäki, Juha S.; Ukkola, Olavi H.; Myerburg, Robert J; Huikuri, Heikki V.

In: Heart Rhythm, Vol. 15, No. 10, 01.10.2018, p. 1450-1456.

Research output: Contribution to journalArticle

Junttila, MJ, Kiviniemi, AM, Lepojärvi, ES, Tulppo, M, Piira, OP, Kenttä, T, Perkiömäki, JS, Ukkola, OH, Myerburg, RJ & Huikuri, HV 2018, 'Type 2 diabetes and coronary artery disease: Preserved ejection fraction and sudden cardiac death', Heart Rhythm, vol. 15, no. 10, pp. 1450-1456. https://doi.org/10.1016/j.hrthm.2018.06.017
Junttila MJ, Kiviniemi AM, Lepojärvi ES, Tulppo M, Piira OP, Kenttä T et al. Type 2 diabetes and coronary artery disease: Preserved ejection fraction and sudden cardiac death. Heart Rhythm. 2018 Oct 1;15(10):1450-1456. https://doi.org/10.1016/j.hrthm.2018.06.017
Junttila, M. Juhani ; Kiviniemi, Antti M. ; Lepojärvi, E. Samuli ; Tulppo, Mikko ; Piira, Olli Pekka ; Kenttä, Tuomas ; Perkiömäki, Juha S. ; Ukkola, Olavi H. ; Myerburg, Robert J ; Huikuri, Heikki V. / Type 2 diabetes and coronary artery disease : Preserved ejection fraction and sudden cardiac death. In: Heart Rhythm. 2018 ; Vol. 15, No. 10. pp. 1450-1456.
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abstract = "Background: Previous studies have shown that type 2 diabetes (DM2) is associated with sudden cardiac death (SCD) risk in post–myocardial infarction patients. The treatment of coronary artery disease (CAD) as well as DM2 has changed over time. Objective: The purpose of this study was to compare the incidence of SCD in DM2 and nondiabetic patients with CAD and preserved ejection fraction (EF) in a prospective observational study (ARTEMIS study). Methods: In 834 DM2 patients and 1112 nondiabetic patients with CAD enrolled, the EF measured ≥3 months after qualifying was 63{\%} ± 10{\%} in DM2 patients and 65{\%} ± 8{\%} in nondiabetic patients (P <.01). The primary end point was SCD or resuscitation from sudden cardiac arrest (SCA). All-cause mortality, cardiac mortality, non-SCD, hospitalization for heart failure, and acute coronary syndrome were secondary end points. Results: During a mean follow-up of 6.3 ± 1.6 years, SCDs/SCAs occurred in 50 patients. The prevalence of SCD/SCA was higher in DM2 patients (4.1{\%}) than in nondiabetic patients (1.4{\%}) (adjusted hazard ratio 2.6; 95{\%} confidence interval 1.3–5.3; P <.01). However, the non-SCD component of cardiac mortality was not significantly different between DM2 and nondiabetic patients. In addition, heart failure hospitalizations were more common in DM2 patients (8.4{\%}) than in nondiabetic patients (2.9{\%}) (P <.001). The annual cardiac mortality in nondiabetic patients with CAD was 0.50{\%}, which was lower than the 0.59{\%} reported in the general Finnish population. Conclusion: DM2 is an independent risk factor for SCD/SCA in CAD patients with preserved EF. Cardiac mortality in nondiabetic CAD patients is slightly lower than that in the general population in the present treatment era.",
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T2 - Preserved ejection fraction and sudden cardiac death

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AU - Kiviniemi, Antti M.

AU - Lepojärvi, E. Samuli

AU - Tulppo, Mikko

AU - Piira, Olli Pekka

AU - Kenttä, Tuomas

AU - Perkiömäki, Juha S.

AU - Ukkola, Olavi H.

AU - Myerburg, Robert J

AU - Huikuri, Heikki V.

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N2 - Background: Previous studies have shown that type 2 diabetes (DM2) is associated with sudden cardiac death (SCD) risk in post–myocardial infarction patients. The treatment of coronary artery disease (CAD) as well as DM2 has changed over time. Objective: The purpose of this study was to compare the incidence of SCD in DM2 and nondiabetic patients with CAD and preserved ejection fraction (EF) in a prospective observational study (ARTEMIS study). Methods: In 834 DM2 patients and 1112 nondiabetic patients with CAD enrolled, the EF measured ≥3 months after qualifying was 63% ± 10% in DM2 patients and 65% ± 8% in nondiabetic patients (P <.01). The primary end point was SCD or resuscitation from sudden cardiac arrest (SCA). All-cause mortality, cardiac mortality, non-SCD, hospitalization for heart failure, and acute coronary syndrome were secondary end points. Results: During a mean follow-up of 6.3 ± 1.6 years, SCDs/SCAs occurred in 50 patients. The prevalence of SCD/SCA was higher in DM2 patients (4.1%) than in nondiabetic patients (1.4%) (adjusted hazard ratio 2.6; 95% confidence interval 1.3–5.3; P <.01). However, the non-SCD component of cardiac mortality was not significantly different between DM2 and nondiabetic patients. In addition, heart failure hospitalizations were more common in DM2 patients (8.4%) than in nondiabetic patients (2.9%) (P <.001). The annual cardiac mortality in nondiabetic patients with CAD was 0.50%, which was lower than the 0.59% reported in the general Finnish population. Conclusion: DM2 is an independent risk factor for SCD/SCA in CAD patients with preserved EF. Cardiac mortality in nondiabetic CAD patients is slightly lower than that in the general population in the present treatment era.

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KW - Coronary artery disease

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KW - Sudden cardiac death

KW - Type 2 diabetes

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