TY - JOUR
T1 - Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy
T2 - A retrospective case series
AU - Liang, Shuting
AU - Shi, Xuan
AU - Rosenfeld, Philip J.
AU - Li, Xiaoxin
N1 - Funding Information:
Funding Bethune - Langmu Ophthalmic Foundation for Young and Middle-aged Researchers (BJ-LM2015001L)
PY - 2018/11
Y1 - 2018/11
N2 - Background and objective To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye. Study design This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA. Results 15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps, BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA. Conclusion BVN and type 2 NV can coexist in the same PCV eye and communicate with each other. This suggests that polyps may represent a structural variant of neovascular tissue rather than a distinct pathogenic process in NV.
AB - Background and objective To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye. Study design This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA. Results 15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps, BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA. Conclusion BVN and type 2 NV can coexist in the same PCV eye and communicate with each other. This suggests that polyps may represent a structural variant of neovascular tissue rather than a distinct pathogenic process in NV.
KW - Optical Coherence Tomography Angiography (OCTA)
KW - Polypoidal Choroidal Vasculopathy (PCV)
KW - neovascular Age-related Macular Degeneration (nAMD)
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U2 - 10.1136/bjophthalmol-2017-311518
DO - 10.1136/bjophthalmol-2017-311518
M3 - Article
C2 - 29436399
AN - SCOPUS:85055190730
VL - 102
SP - 1570
EP - 1574
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 11
ER -