Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons

S. D. Dib-Hajj, L. Tyrrell, T. R. Cummins, J. A. Black, P. M. Wood, S. G. Waxman

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalFEBS letters
Volume462
Issue number1-2
DOIs
StatePublished - Nov 26 1999

Keywords

  • Na current kinetics
  • Nociceptive neuron
  • Spinal sensory neuron

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Dib-Hajj, S. D., Tyrrell, L., Cummins, T. R., Black, J. A., Wood, P. M., & Waxman, S. G. (1999). Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons. FEBS letters, 462(1-2), 117-120. https://doi.org/10.1016/S0014-5793(99)01519-7