Abstract
Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | FEBS letters |
| Volume | 462 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 26 1999 |
Keywords
- Na current kinetics
- Nociceptive neuron
- Spinal sensory neuron
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Dib-Hajj, S. D., Tyrrell, L., Cummins, T. R., Black, J. A., Wood, P. M., & Waxman, S. G. (1999). Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons. FEBS letters, 462(1-2), 117-120. https://doi.org/10.1016/S0014-5793(99)01519-7