Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons

S. D. Dib-Hajj; L. Tyrrell; T. R. Cummins; J. A. Black; P. M. Wood; S. G. Waxman

doi:10.1016/S0014-5793(99)01519-7

Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons

S. D. Dib-Hajj, L. Tyrrell, T. R. Cummins, J. A. Black, P. M. Wood, S. G. Waxman

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

Original language	English (US)
Pages (from-to)	117-120
Number of pages	4
Journal	FEBS letters
Volume	462
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(99)01519-7
State	Published - Nov 26 1999

Keywords

Na current kinetics
Nociceptive neuron
Spinal sensory neuron

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/S0014-5793(99)01519-7

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title = "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons",

abstract = "Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.",

keywords = "Na current kinetics, Nociceptive neuron, Spinal sensory neuron",

author = "Dib-Hajj, {S. D.} and L. Tyrrell and Cummins, {T. R.} and Black, {J. A.} and Wood, {P. M.} and Waxman, {S. G.}",

note = "Funding Information: Adult human DRG was kindly provided by Les Olson and the University of Miami Organ Procurement Team. This work was supported in part by grants from the Medical Research Service and the Rehabilitation Research Service, Department of Veterans Affairs, and by grants from The Eastern Paralyzed Veterans Association and the Paralyzed Veterans of America (S.G.W.), and NINDS Grant NS09923-28 (P.W.).",

year = "1999",

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doi = "10.1016/S0014-5793(99)01519-7",

language = "English (US)",

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pages = "117--120",

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T1 - Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons

AU - Dib-Hajj, S. D.

AU - Tyrrell, L.

AU - Cummins, T. R.

AU - Black, J. A.

AU - Wood, P. M.

AU - Waxman, S. G.

N1 - Funding Information: Adult human DRG was kindly provided by Les Olson and the University of Miami Organ Procurement Team. This work was supported in part by grants from the Medical Research Service and the Rehabilitation Research Service, Department of Veterans Affairs, and by grants from The Eastern Paralyzed Veterans Association and the Paralyzed Veterans of America (S.G.W.), and NINDS Grant NS09923-28 (P.W.).

PY - 1999/11/26

Y1 - 1999/11/26

N2 - Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

AB - Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

KW - Na current kinetics

KW - Nociceptive neuron

KW - Spinal sensory neuron

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