Two successful pregnancies in a woman with chronic thrombotic thrombocytopenic purpura treated by plasma infusion

Eric C.‐Y Lian, John J. Byrnes, Donald R. Harkness

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A 21-year-old primigravida in her 20th week of pregnancy developed TTP. She was managed with weekly or semiweekly plasma infusions and delivered a healthy 1.6 kg baby 2 weeks prior to the expected data of delivery. After delivery she continued to have active TTP with thrombocytopenia which responded repeatedly to plasma infusion through their frequency gradually decreased to about one unit every 3-4 weeks. Three years after the birth of the first child she conceived again and was easily managed with repeated plasma infusions although the frequency and amount of plasma required to prevent thrombocytopenia were increased. She delivered a normal 3.4 kg term baby after which she again had a decreased plasma requirement. This is the first report of a woman with 5 years of active TTP managed with plasma alone. She experienced two pregnancies in which both mother and infant survived. We believe that the use of plasma in the management of TTP during pregnancy will improve the survival rate of both mother and infant. At the time of second birth, the platelet count was low in the mother but normal in the baby. This suggests that the platelet depressing factor of this patient does not cross the placental barrier.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalAmerican Journal of Hematology
Volume16
Issue number3
DOIs
StatePublished - Apr 1984

Keywords

  • plasma infusion
  • pregnancy
  • thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Two successful pregnancies in a woman with chronic thrombotic thrombocytopenic purpura treated by plasma infusion'. Together they form a unique fingerprint.

  • Cite this