Two strategies to increase adherence to HIV antiretroviral medication: Life-Steps and medication monitoring

Steven A. Safren, Michael W. Otto, Jonathan L. Worth, Elizabeth Salomon, William Johnson, Kenneth Mayer, Steven Boswell

Research output: Contribution to journalArticlepeer-review

241 Scopus citations


Advances in the medical treatment of HIV have made it clear that adherence to highly active antiretroviral treatment is a crucial feature for treatment success. The present paper had two goals: (1) to examine psychosocial predictors of adherence in persons receiving HIV antiretroviral therapy; (2) to compared two minimal-treatment interventions to increase HIV medication adherence in a subset of persons who self-reported less than perfect adherence. One of the interventions, Life-Steps, is a single-session intervention utilizing cognitive-behavioral, motivational interviewing, and problem-solving techniques. The other intervention, self-monitoring, utilizes a pill-diary and an adherence questionnaire alone. Significant correlates of adherence included depression, social support, adherence self-efficacy, and punishment beliefs about HIV. Depression was a significant unique predictor of adherence over and above the other variables. Both interventions yielded improvement in adherence from baseline, and the Life-Steps intervention showed faster improvements in adherence for persons with extant adherence problems.

Original languageEnglish (US)
Pages (from-to)1151-1162
Number of pages12
JournalBehaviour Research and Therapy
Issue number10
StatePublished - 2001
Externally publishedYes


  • AIDS
  • Adherence
  • Antiretroviral therapy
  • Compliance
  • HIV

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Clinical Psychology
  • Psychiatry and Mental health


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