### Abstract

A two-patch model for the spread of West Nile virus between two discrete geographic regions is established to incorporate a mobility process which describes how contact transmission occurs between individuals from and between two regions. In the mobility process, we assume that the host birds can migrate between regions, but not the mosquitoes. The basic reproduction number (Formula presented.) is computed by the next generation matrix method. We prove that if (Formula presented.), then the disease-free equilibrium is globally asymptotically stable. If (Formula presented.), the endemic equilibrium is globally asymptotically stable for any nonnegative nontrivial initial data. Using the perturbation theory, we obtain the concrete expression of the endemic equilibrium of the model with a mild restriction of the birds movement rate between patches. Finally, numerical simulations demonstrate that the disease becomes endemic in both patches when birds move back and forth between the two regions. Some numerical simulations for (Formula presented.) in terms of the birds movement rate are performed which show that the impacts could be very complicated.

Original language | English (US) |
---|---|

Pages (from-to) | 1-24 |

Number of pages | 24 |

Journal | Bulletin of Mathematical Biology |

DOIs | |

State | Accepted/In press - Feb 28 2018 |

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### Keywords

- Basic reproduction number
- Birds migration
- Mosquitoes
- Patch model
- Stability
- West Nile virus

### ASJC Scopus subject areas

- Neuroscience(all)
- Immunology
- Mathematics(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Pharmacology
- Agricultural and Biological Sciences(all)
- Computational Theory and Mathematics

### Cite this

*Bulletin of Mathematical Biology*, 1-24. https://doi.org/10.1007/s11538-018-0404-8

**Two-patch model for the spread of West Nile virus.** / Zhang, Juping; Cosner, George; Zhu, Huaiping.

Research output: Contribution to journal › Article

*Bulletin of Mathematical Biology*, pp. 1-24. https://doi.org/10.1007/s11538-018-0404-8

}

TY - JOUR

T1 - Two-patch model for the spread of West Nile virus

AU - Zhang, Juping

AU - Cosner, George

AU - Zhu, Huaiping

PY - 2018/2/28

Y1 - 2018/2/28

N2 - A two-patch model for the spread of West Nile virus between two discrete geographic regions is established to incorporate a mobility process which describes how contact transmission occurs between individuals from and between two regions. In the mobility process, we assume that the host birds can migrate between regions, but not the mosquitoes. The basic reproduction number (Formula presented.) is computed by the next generation matrix method. We prove that if (Formula presented.), then the disease-free equilibrium is globally asymptotically stable. If (Formula presented.), the endemic equilibrium is globally asymptotically stable for any nonnegative nontrivial initial data. Using the perturbation theory, we obtain the concrete expression of the endemic equilibrium of the model with a mild restriction of the birds movement rate between patches. Finally, numerical simulations demonstrate that the disease becomes endemic in both patches when birds move back and forth between the two regions. Some numerical simulations for (Formula presented.) in terms of the birds movement rate are performed which show that the impacts could be very complicated.

AB - A two-patch model for the spread of West Nile virus between two discrete geographic regions is established to incorporate a mobility process which describes how contact transmission occurs between individuals from and between two regions. In the mobility process, we assume that the host birds can migrate between regions, but not the mosquitoes. The basic reproduction number (Formula presented.) is computed by the next generation matrix method. We prove that if (Formula presented.), then the disease-free equilibrium is globally asymptotically stable. If (Formula presented.), the endemic equilibrium is globally asymptotically stable for any nonnegative nontrivial initial data. Using the perturbation theory, we obtain the concrete expression of the endemic equilibrium of the model with a mild restriction of the birds movement rate between patches. Finally, numerical simulations demonstrate that the disease becomes endemic in both patches when birds move back and forth between the two regions. Some numerical simulations for (Formula presented.) in terms of the birds movement rate are performed which show that the impacts could be very complicated.

KW - Basic reproduction number

KW - Birds migration

KW - Mosquitoes

KW - Patch model

KW - Stability

KW - West Nile virus

UR - http://www.scopus.com/inward/record.url?scp=85042630048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042630048&partnerID=8YFLogxK

U2 - 10.1007/s11538-018-0404-8

DO - 10.1007/s11538-018-0404-8

M3 - Article

C2 - 29492829

AN - SCOPUS:85042630048

SP - 1

EP - 24

JO - Bulletin of Mathematical Biology

JF - Bulletin of Mathematical Biology

SN - 0092-8240

ER -