TY - JOUR
T1 - Two long terminal repeat circles and persistent HIV-1 replication
AU - Sharkey, Mark E.
AU - Stevenson, Mario
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Building on the success of combination antiretroviral drug therapy will require a better understanding of the underlying basis for viral persistence. Characterization of the therapeutic, viral, and immunological factors that influence the size and stability of viral reservoirs will foster the development of strategies to control or eliminate HIV-1 from infected individuals. Here we review recent work aimed at delineating the complex interplay between viral replication, the immune system, and viral reservoirs. Finally, we address the implications and clinical significance of the residual replication that persists in infected individuals on potent antiretroviral therapy to evaluate both the possible risks and benefits of ongoing HIV-1 replication.
AB - Building on the success of combination antiretroviral drug therapy will require a better understanding of the underlying basis for viral persistence. Characterization of the therapeutic, viral, and immunological factors that influence the size and stability of viral reservoirs will foster the development of strategies to control or eliminate HIV-1 from infected individuals. Here we review recent work aimed at delineating the complex interplay between viral replication, the immune system, and viral reservoirs. Finally, we address the implications and clinical significance of the residual replication that persists in infected individuals on potent antiretroviral therapy to evaluate both the possible risks and benefits of ongoing HIV-1 replication.
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U2 - 10.1097/00001432-200102000-00002
DO - 10.1097/00001432-200102000-00002
M3 - Review article
C2 - 11979108
AN - SCOPUS:0035146288
VL - 14
SP - 5
EP - 11
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
SN - 0951-7375
IS - 1
ER -