Two different primate species express an identical functional MHC class I allele

David T. Evans, Marian S. Piekarczyk, Luis Cadavid, Virginia S. Hinshaw, David Watkins

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The products of the highly polymorphic and variable major histocompatibility complex (MHC) class I loci play a crucial role in host defenses against infectious disease. While similar alleles have been found in closely related species, sharing of a functional MHC class I allele between two species has never been reported. Here we show that an identical functional MHC class I molecule is present in two different primate species with an approximate divergence time of 0.7 million years. Lymphocytes from the red-crested tamarin (Saguinus geoffroyi) expressed an MHC class I allele (Sage-G*01) that was identical in coding sequence to an MHC class I allele (Sage-G*08) found in the cotton-top tamarin (Saguinus oedipus). Furthermore, influenza virus-specific cytotoxic T lymphocytes (CTLs) generated in the cotton-top tamarin killed lymphocytes expressing the influenza virus nucleoprotein (NP) from the red-crested tamarin. Since the influenza virus NP epitope is bound by Sage-G*08 in the cotton-top tamarin, it is likely that this molecule is functional in both species. These data provide the first evidence that functional MHC class I molecules can be maintained entirely intact in two separate species.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalImmunogenetics
Volume47
Issue number3
DOIs
StatePublished - Feb 13 1998
Externally publishedYes

Fingerprint

Major Histocompatibility Complex
Primates
Alleles
Saguinus
Orthomyxoviridae
Nucleoproteins
Lymphocytes
Cytotoxic T-Lymphocytes
Communicable Diseases
Epitopes

Keywords

  • Cotton-top tamarin
  • Cytotoxic T lymphocytes
  • Influenza
  • MHC class I
  • New World Primates

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Two different primate species express an identical functional MHC class I allele. / Evans, David T.; Piekarczyk, Marian S.; Cadavid, Luis; Hinshaw, Virginia S.; Watkins, David.

In: Immunogenetics, Vol. 47, No. 3, 13.02.1998, p. 206-211.

Research output: Contribution to journalArticle

Evans, David T. ; Piekarczyk, Marian S. ; Cadavid, Luis ; Hinshaw, Virginia S. ; Watkins, David. / Two different primate species express an identical functional MHC class I allele. In: Immunogenetics. 1998 ; Vol. 47, No. 3. pp. 206-211.
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