Turnover of ribosomal RNA in rat liver

John N. Loeb, R. Howell, Gordon M. Tomkins

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.

Original languageEnglish
Pages (from-to)1093-1095
Number of pages3
JournalScience
Volume149
Issue number3688
StatePublished - Dec 1 1965
Externally publishedYes

Fingerprint

Orotic Acid
Ribosomal RNA
Half-Life
Injections
Liver
Proteins

ASJC Scopus subject areas

  • General

Cite this

Loeb, J. N., Howell, R., & Tomkins, G. M. (1965). Turnover of ribosomal RNA in rat liver. Science, 149(3688), 1093-1095.

Turnover of ribosomal RNA in rat liver. / Loeb, John N.; Howell, R.; Tomkins, Gordon M.

In: Science, Vol. 149, No. 3688, 01.12.1965, p. 1093-1095.

Research output: Contribution to journalArticle

Loeb, JN, Howell, R & Tomkins, GM 1965, 'Turnover of ribosomal RNA in rat liver', Science, vol. 149, no. 3688, pp. 1093-1095.
Loeb JN, Howell R, Tomkins GM. Turnover of ribosomal RNA in rat liver. Science. 1965 Dec 1;149(3688):1093-1095.
Loeb, John N. ; Howell, R. ; Tomkins, Gordon M. / Turnover of ribosomal RNA in rat liver. In: Science. 1965 ; Vol. 149, No. 3688. pp. 1093-1095.
@article{ae092158108b4603b6a6b826dd90527c,
title = "Turnover of ribosomal RNA in rat liver",
abstract = "After a single injection of radioactive orotic acid and a {"}chase{"} of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.",
author = "Loeb, {John N.} and R. Howell and Tomkins, {Gordon M.}",
year = "1965",
month = "12",
day = "1",
language = "English",
volume = "149",
pages = "1093--1095",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "3688",

}

TY - JOUR

T1 - Turnover of ribosomal RNA in rat liver

AU - Loeb, John N.

AU - Howell, R.

AU - Tomkins, Gordon M.

PY - 1965/12/1

Y1 - 1965/12/1

N2 - After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.

AB - After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.

UR - http://www.scopus.com/inward/record.url?scp=37049243465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049243465&partnerID=8YFLogxK

M3 - Article

C2 - 5826520

AN - SCOPUS:37049243465

VL - 149

SP - 1093

EP - 1095

JO - Science

JF - Science

SN - 0036-8075

IS - 3688

ER -