Turnover of ribosomal RNA in rat liver

John N. Loeb, R. Rodney Howell, Gordon M. Tomkins

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.

Original languageEnglish (US)
Pages (from-to)1093-1095
Number of pages3
Issue number3688
StatePublished - 1965
Externally publishedYes

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