Turnover of ribosomal RNA in rat liver

John N. Loeb; R. Rodney Howell; Gordon M. Tomkins

doi:10.1126/science.149.3688.1093

Turnover of ribosomal RNA in rat liver

John N. Loeb, R. Rodney Howell, Gordon M. Tomkins

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about 5 days. The possible significance of this result is discussed with regard to control of protein synthesis.

Original language	English (US)
Pages (from-to)	1093-1095
Number of pages	3
Journal	Science
Volume	149
Issue number	3688
DOIs	https://doi.org/10.1126/science.149.3688.1093
State	Published - Jan 1 1965
Externally published	Yes

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