Tumour necrosis factor receptor 1 and mortality in a multi-ethnic cohort: The northern manhattan study

Jorge M. Luna, Yeseon Moon, Khin Liu, Steven Spitalnik, Myunghee Paik, Ralph L Sacco, Mitchell S V Elkind

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: to study the association between soluble tumour necrosis factor receptor 1 (sTNFR1) levels and mortality in the population-based Northern Manhattan Study (NOMAS). Methods: NOMAS is a multi-ethnic, community-based cohort study with mean 8.4 years of follow-up. sTNFR1 was measured using ELISA. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals (HR, 95% CI) for the association of sTNFR1 with risk of all-cause mortality after adjusting for relevant confounders. Results: sTNFR1 measurements were available in 1,862 participants (mean age 69.2 ± 10.2 years) with 512 all-cause deaths. Median sTNFR1 was 2.28 ng/ml. Those with sTNFR1 levels in the highest quartile (Q4), compared with those with sTNFR1 in the lowest quartile (Q1), were at an increased risk of all-cause mortality (adjusted HR: 1.8, 95% CI: 1.4-2.4) and non-vascular mortality (adjusted HR: 2.5, 95% CI: 1.5-3.6), but not vascular mortality (adjusted HR: 1.3, 95% CI: 0.9-1.9). There were interactions between sTNFR1 quartiles and medical insurance-status [likelihood ratio test (LRT) with 3 degrees of freedom, Pinteraction = 0.02] and alcohol consumption (LRT with 3 degrees of freedom, Pinteraction < 0.01) for all-cause mortality. In participants with no insurance or Medicaid, those with sTNFR1 in the top quartile had nearly a threefold increased risk of total mortality than the lowest quartile (adjusted HR: 2.9, 95% CI: 1.9-4.4). Conclusion: in this multi-ethnic cohort, sTNFR1 was associated with all-cause and non-vascular mortality, particularly among those of a lower socioeconomic status.

Original languageEnglish
Article numberafs175
Pages (from-to)385-390
Number of pages6
JournalAge and Ageing
Volume42
Issue number3
DOIs
StatePublished - May 1 2013

Fingerprint

Tumor Necrosis Factor Receptors
Mortality
Insurance Coverage
Medicaid
Insurance
Proportional Hazards Models
Social Class
Alcohol Drinking
Blood Vessels
Cause of Death
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Confidence Intervals

Keywords

  • Alcohol use
  • Inflammation
  • Insurance status
  • Mortality risk
  • Older people

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Luna, J. M., Moon, Y., Liu, K., Spitalnik, S., Paik, M., Sacco, R. L., & Elkind, M. S. V. (2013). Tumour necrosis factor receptor 1 and mortality in a multi-ethnic cohort: The northern manhattan study. Age and Ageing, 42(3), 385-390. [afs175]. https://doi.org/10.1093/ageing/afs175

Tumour necrosis factor receptor 1 and mortality in a multi-ethnic cohort : The northern manhattan study. / Luna, Jorge M.; Moon, Yeseon; Liu, Khin; Spitalnik, Steven; Paik, Myunghee; Sacco, Ralph L; Elkind, Mitchell S V.

In: Age and Ageing, Vol. 42, No. 3, afs175, 01.05.2013, p. 385-390.

Research output: Contribution to journalArticle

Luna, JM, Moon, Y, Liu, K, Spitalnik, S, Paik, M, Sacco, RL & Elkind, MSV 2013, 'Tumour necrosis factor receptor 1 and mortality in a multi-ethnic cohort: The northern manhattan study', Age and Ageing, vol. 42, no. 3, afs175, pp. 385-390. https://doi.org/10.1093/ageing/afs175
Luna, Jorge M. ; Moon, Yeseon ; Liu, Khin ; Spitalnik, Steven ; Paik, Myunghee ; Sacco, Ralph L ; Elkind, Mitchell S V. / Tumour necrosis factor receptor 1 and mortality in a multi-ethnic cohort : The northern manhattan study. In: Age and Ageing. 2013 ; Vol. 42, No. 3. pp. 385-390.
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abstract = "Objective: to study the association between soluble tumour necrosis factor receptor 1 (sTNFR1) levels and mortality in the population-based Northern Manhattan Study (NOMAS). Methods: NOMAS is a multi-ethnic, community-based cohort study with mean 8.4 years of follow-up. sTNFR1 was measured using ELISA. Cox proportional hazards models were used to calculate hazard ratios and 95{\%} confidence intervals (HR, 95{\%} CI) for the association of sTNFR1 with risk of all-cause mortality after adjusting for relevant confounders. Results: sTNFR1 measurements were available in 1,862 participants (mean age 69.2 ± 10.2 years) with 512 all-cause deaths. Median sTNFR1 was 2.28 ng/ml. Those with sTNFR1 levels in the highest quartile (Q4), compared with those with sTNFR1 in the lowest quartile (Q1), were at an increased risk of all-cause mortality (adjusted HR: 1.8, 95{\%} CI: 1.4-2.4) and non-vascular mortality (adjusted HR: 2.5, 95{\%} CI: 1.5-3.6), but not vascular mortality (adjusted HR: 1.3, 95{\%} CI: 0.9-1.9). There were interactions between sTNFR1 quartiles and medical insurance-status [likelihood ratio test (LRT) with 3 degrees of freedom, Pinteraction = 0.02] and alcohol consumption (LRT with 3 degrees of freedom, Pinteraction < 0.01) for all-cause mortality. In participants with no insurance or Medicaid, those with sTNFR1 in the top quartile had nearly a threefold increased risk of total mortality than the lowest quartile (adjusted HR: 2.9, 95{\%} CI: 1.9-4.4). Conclusion: in this multi-ethnic cohort, sTNFR1 was associated with all-cause and non-vascular mortality, particularly among those of a lower socioeconomic status.",
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