Tumors and diseases of the joint

G. Petur Nielsen, Andrew Rosenberg, John X. O'Connell, Susan V. Kattapuram, Alan L. Schiller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A variety of different diseases affect the synovium, including infection, noninfectious immunologic inflammatory conditions, degenerative arthroses, crystal deposits, trauma, and tumors. Tumors of the synovium are relatively uncommon. Any mesenchymal tumor may arise in the synovium, but most recapitulate its normal counterpart including synoviocytes, blood vessels, fat, and fibrous tissue. These tumors can arise in any synovial lined structures both within joints and in extraarticular locations. Most synovial tumors are benign. Malignant tumors are rare but important to recognize because many are aggressive and must be treated appropriately. Among common nonneoplastic conditions that affect the synovium and surrounding structures are crystal deposits such as monosodium urate crystals, calcium pyrophosphate dihydrate crystals, and hydroxyapatite crystals. These crystal deposits may be asymptomatic or cause severe pain or chronic joint destruction. Their accurate identification is important to guide appropriate therapy.

Original languageEnglish
Pages (from-to)37-52
Number of pages16
JournalSeminars in Diagnostic Pathology
Volume28
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Fingerprint

Joint Diseases
Synovial Membrane
Neoplasms
Joints
Calcium Pyrophosphate
Durapatite
Uric Acid
Chronic Pain
Blood Vessels
Fats
Wounds and Injuries
Infection

Keywords

  • Crystal deposition
  • Synovium
  • Tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nielsen, G. P., Rosenberg, A., O'Connell, J. X., Kattapuram, S. V., & Schiller, A. L. (2011). Tumors and diseases of the joint. Seminars in Diagnostic Pathology, 28(1), 37-52. https://doi.org/10.1053/j.semdp.2011.02.009

Tumors and diseases of the joint. / Nielsen, G. Petur; Rosenberg, Andrew; O'Connell, John X.; Kattapuram, Susan V.; Schiller, Alan L.

In: Seminars in Diagnostic Pathology, Vol. 28, No. 1, 01.02.2011, p. 37-52.

Research output: Contribution to journalArticle

Nielsen, GP, Rosenberg, A, O'Connell, JX, Kattapuram, SV & Schiller, AL 2011, 'Tumors and diseases of the joint', Seminars in Diagnostic Pathology, vol. 28, no. 1, pp. 37-52. https://doi.org/10.1053/j.semdp.2011.02.009
Nielsen GP, Rosenberg A, O'Connell JX, Kattapuram SV, Schiller AL. Tumors and diseases of the joint. Seminars in Diagnostic Pathology. 2011 Feb 1;28(1):37-52. https://doi.org/10.1053/j.semdp.2011.02.009
Nielsen, G. Petur ; Rosenberg, Andrew ; O'Connell, John X. ; Kattapuram, Susan V. ; Schiller, Alan L. / Tumors and diseases of the joint. In: Seminars in Diagnostic Pathology. 2011 ; Vol. 28, No. 1. pp. 37-52.
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