Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation

C. F. Wu, H. Nakamura, A. P Y Chan, Y. H. Zhou, Tongyu Wikramanayake, J. Kuang, S. G. Gong, G. He, L. D. Etkin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Tumorhead (TH) is a novel maternal gene product from Xenopus laevis containing several basic domains and a weak coiled-coil. Overexpression of wild-type TH resulted in increased proliferation of neural plate cells, causing expansion of the neural field followed by neural tube and craniofacial abnormalities. Overexpressed TH protein repressed neural differentiation and neural crest markers, but did not inhibit the neural inducers, pan-neural markers or mesodermal markers. Loss of function by injection of anti-TH antibody inhibited cell proliferation. Our data are consistent with a model in which tumorhead functions in regulating differentiation of the neural tissues but not neural induction or determination through its effect on cell proliferation.

Original languageEnglish
Pages (from-to)3381-3393
Number of pages13
JournalDevelopment
Volume128
Issue number17
StatePublished - Oct 10 2001
Externally publishedYes

Fingerprint

Xenopus
Craniofacial Abnormalities
Cell Proliferation
Neural Plate
Neural Tube
Neural Crest
Xenopus laevis
Genes
Anti-Idiotypic Antibodies
Mothers
Injections
Proteins

Keywords

  • Cell proliferation
  • Maternal genes
  • Neural differentiation
  • Oocyte
  • Xenopus laevis

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Wu, C. F., Nakamura, H., Chan, A. P. Y., Zhou, Y. H., Wikramanayake, T., Kuang, J., ... Etkin, L. D. (2001). Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. Development, 128(17), 3381-3393.

Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. / Wu, C. F.; Nakamura, H.; Chan, A. P Y; Zhou, Y. H.; Wikramanayake, Tongyu; Kuang, J.; Gong, S. G.; He, G.; Etkin, L. D.

In: Development, Vol. 128, No. 17, 10.10.2001, p. 3381-3393.

Research output: Contribution to journalArticle

Wu, CF, Nakamura, H, Chan, APY, Zhou, YH, Wikramanayake, T, Kuang, J, Gong, SG, He, G & Etkin, LD 2001, 'Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation', Development, vol. 128, no. 17, pp. 3381-3393.
Wu, C. F. ; Nakamura, H. ; Chan, A. P Y ; Zhou, Y. H. ; Wikramanayake, Tongyu ; Kuang, J. ; Gong, S. G. ; He, G. ; Etkin, L. D. / Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. In: Development. 2001 ; Vol. 128, No. 17. pp. 3381-3393.
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