Tumor suppressor genes in ophthalmology

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tumor suppressor genes have a diversity of functions, but they have in common the property of inhibiting neoplastic transformation. When they become inactivated, a constraint is removed that allows cells to grow inappropriately. Mutations in these genes are now thought to be the initiating events in most cancers. The first tumor suppressor gene was discovered through its role in retinoblastoma, and many other tumor suppressor genes also have important ophthalmic manifestations. The first group of tumor suppressor genes to be discussed are those involved in retinoblastoma and uveal melanoma. These are among the most frequently mutated genes in human cancer and are key regulators of growth and homeostasis. The second group of genes is associated with specific hereditary tumor syndromes with ophthalmic manifestations. These genes function in a variety of molecular pathways and are associated with neoplastic and non-neoplastic abnormalities in restricted tissue distributions. Research on tumor suppressor genes continues to shed light on the molecular pathophysiology of ophthalmic tumors and will increasingly yield diagnostic and therapeutic applications. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalSurvey of Ophthalmology
Volume44
Issue number3
DOIs
StatePublished - Nov 1 1999
Externally publishedYes

Fingerprint

Ophthalmology
Tumor Suppressor Genes
Eye Manifestations
Retinoblastoma
Genes
Neoplasms
Tissue Distribution
Homeostasis
Mutation
Growth
Research

Keywords

  • Adenomatous polyposis coli
  • Neurofibromatosis
  • Retinoblastoma
  • Tuberous sclerosis
  • Tumor suppressor genes
  • Uveal melanoma
  • von Hippel-Lindau syndrome

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tumor suppressor genes in ophthalmology. / William Harbour, J.

In: Survey of Ophthalmology, Vol. 44, No. 3, 01.11.1999, p. 235-246.

Research output: Contribution to journalArticle

@article{ce7d00c16d664262b2bf22f572e384a4,
title = "Tumor suppressor genes in ophthalmology",
abstract = "Tumor suppressor genes have a diversity of functions, but they have in common the property of inhibiting neoplastic transformation. When they become inactivated, a constraint is removed that allows cells to grow inappropriately. Mutations in these genes are now thought to be the initiating events in most cancers. The first tumor suppressor gene was discovered through its role in retinoblastoma, and many other tumor suppressor genes also have important ophthalmic manifestations. The first group of tumor suppressor genes to be discussed are those involved in retinoblastoma and uveal melanoma. These are among the most frequently mutated genes in human cancer and are key regulators of growth and homeostasis. The second group of genes is associated with specific hereditary tumor syndromes with ophthalmic manifestations. These genes function in a variety of molecular pathways and are associated with neoplastic and non-neoplastic abnormalities in restricted tissue distributions. Research on tumor suppressor genes continues to shed light on the molecular pathophysiology of ophthalmic tumors and will increasingly yield diagnostic and therapeutic applications. Copyright (C) 1999 Elsevier Science Inc.",
keywords = "Adenomatous polyposis coli, Neurofibromatosis, Retinoblastoma, Tuberous sclerosis, Tumor suppressor genes, Uveal melanoma, von Hippel-Lindau syndrome",
author = "{William Harbour}, J.",
year = "1999",
month = "11",
day = "1",
doi = "10.1016/S0039-6257(99)00102-2",
language = "English",
volume = "44",
pages = "235--246",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Tumor suppressor genes in ophthalmology

AU - William Harbour, J.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Tumor suppressor genes have a diversity of functions, but they have in common the property of inhibiting neoplastic transformation. When they become inactivated, a constraint is removed that allows cells to grow inappropriately. Mutations in these genes are now thought to be the initiating events in most cancers. The first tumor suppressor gene was discovered through its role in retinoblastoma, and many other tumor suppressor genes also have important ophthalmic manifestations. The first group of tumor suppressor genes to be discussed are those involved in retinoblastoma and uveal melanoma. These are among the most frequently mutated genes in human cancer and are key regulators of growth and homeostasis. The second group of genes is associated with specific hereditary tumor syndromes with ophthalmic manifestations. These genes function in a variety of molecular pathways and are associated with neoplastic and non-neoplastic abnormalities in restricted tissue distributions. Research on tumor suppressor genes continues to shed light on the molecular pathophysiology of ophthalmic tumors and will increasingly yield diagnostic and therapeutic applications. Copyright (C) 1999 Elsevier Science Inc.

AB - Tumor suppressor genes have a diversity of functions, but they have in common the property of inhibiting neoplastic transformation. When they become inactivated, a constraint is removed that allows cells to grow inappropriately. Mutations in these genes are now thought to be the initiating events in most cancers. The first tumor suppressor gene was discovered through its role in retinoblastoma, and many other tumor suppressor genes also have important ophthalmic manifestations. The first group of tumor suppressor genes to be discussed are those involved in retinoblastoma and uveal melanoma. These are among the most frequently mutated genes in human cancer and are key regulators of growth and homeostasis. The second group of genes is associated with specific hereditary tumor syndromes with ophthalmic manifestations. These genes function in a variety of molecular pathways and are associated with neoplastic and non-neoplastic abnormalities in restricted tissue distributions. Research on tumor suppressor genes continues to shed light on the molecular pathophysiology of ophthalmic tumors and will increasingly yield diagnostic and therapeutic applications. Copyright (C) 1999 Elsevier Science Inc.

KW - Adenomatous polyposis coli

KW - Neurofibromatosis

KW - Retinoblastoma

KW - Tuberous sclerosis

KW - Tumor suppressor genes

KW - Uveal melanoma

KW - von Hippel-Lindau syndrome

UR - http://www.scopus.com/inward/record.url?scp=0032717574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032717574&partnerID=8YFLogxK

U2 - 10.1016/S0039-6257(99)00102-2

DO - 10.1016/S0039-6257(99)00102-2

M3 - Article

VL - 44

SP - 235

EP - 246

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 3

ER -