Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer

W. J. Levin, G. Casey, Juan Carlos Ramos, M. J. Arboleda, P. T. Reissmann, D. J. Slamon

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription factor genes. Immunohistochemical analysis showed that 32% of evaluable cases studied contained absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 58% of these cancers contained structural alterations of this gene, whereas only 45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c-fos, c-jun, and ECR, in that less expression of these genes was evident in the tumors compared with adjacent normal tissue. Understanding both the biologic and molecular significance of these findings may allow us to explore novel modalities for treatment of this disease.

Original languageEnglish
JournalChest
Volume106
Issue number6 SUPPL.
StatePublished - Jan 1 1994
Externally publishedYes

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Genetic Transcription
Non-Small Cell Lung Carcinoma
Transcription Factors
Lung Neoplasms
Neoplasms
p53 Genes
Tumor Suppressor Genes
Oncogenes
Northern Blotting
Sequence Analysis
Intercellular Signaling Peptides and Proteins
Gene Expression
Messenger RNA
Genes
Proteins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Levin, W. J., Casey, G., Carlos Ramos, J., Arboleda, M. J., Reissmann, P. T., & Slamon, D. J. (1994). Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer. Chest, 106(6 SUPPL.).

Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer. / Levin, W. J.; Casey, G.; Carlos Ramos, Juan; Arboleda, M. J.; Reissmann, P. T.; Slamon, D. J.

In: Chest, Vol. 106, No. 6 SUPPL., 01.01.1994.

Research output: Contribution to journalArticle

Levin, WJ, Casey, G, Carlos Ramos, J, Arboleda, MJ, Reissmann, PT & Slamon, DJ 1994, 'Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer', Chest, vol. 106, no. 6 SUPPL..
Levin WJ, Casey G, Carlos Ramos J, Arboleda MJ, Reissmann PT, Slamon DJ. Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer. Chest. 1994 Jan 1;106(6 SUPPL.).
Levin, W. J. ; Casey, G. ; Carlos Ramos, Juan ; Arboleda, M. J. ; Reissmann, P. T. ; Slamon, D. J. / Tumor suppressor and immediate early transcription factor genes in non- small cell lung cancer. In: Chest. 1994 ; Vol. 106, No. 6 SUPPL.
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