Tumor necrosis factor-alpha levels in HIV-1 seropositive injecting drug users

Raymond L. Ownby, Adarsh M. Kumar, J. Benny Fernandez, Irina Moleon-Borodowsky, Louis Gonzalez, Seth Eisdorfer, Drenna Waldrop-Valverde, Mahendra Kumar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

TNF-α is a highly pleiotropic cytokine and plays an important role in regulating HIV-1 replication. It may compromise the integrity of the blood-brain-barrier and, thus, may contribute to the neurotoxicity of HIV-1-infection. Both intravenous drug abuse (IDU) and HIV infection can increase TNF-α activity, but little information is available on the effects of a combination of these factors on TNF-α. We investigated plasma TNF-α levels and mRNA in the peripheral monocytes of 166 men and women in three groups: HIV-1-positive IDUs, HIV-1-negative IDUs, and HIV-negative non-IDU control participants. HIV-1-positive IDUs had higher TNF-α levels than HIV-1-negative IDUs who, in turn, had higher levels than controls. TNF-α mRNA expression in peripheral monocytes was significantly increased in both HIV-1-positive and negative IDUs compared to controls. These findings show that the effects of HIV infection and intravenous drug use may be additive in increasing TNF-α levels. Given the multiple effects of TNF-α in HIV infection, additional investigation of its role is needed.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalJournal of Neuroimmune Pharmacology
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2009

Keywords

  • Cognition
  • Dementia
  • Drug abuse
  • HIV-1
  • Immune function
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology
  • Immunology and Allergy
  • Immunology
  • Neuroscience (miscellaneous)

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  • Cite this

    Ownby, R. L., Kumar, A. M., Benny Fernandez, J., Moleon-Borodowsky, I., Gonzalez, L., Eisdorfer, S., Waldrop-Valverde, D., & Kumar, M. (2009). Tumor necrosis factor-alpha levels in HIV-1 seropositive injecting drug users. Journal of Neuroimmune Pharmacology, 4(3), 350-358. https://doi.org/10.1007/s11481-009-9150-x