Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma

B. A. Roos, M. J. Yoon, A. L. Frelinger, A. E. Pensky, R. S. Birnbaum, P. W. Lambert

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have recently reported immunochemical methods for the measurement and purification of rat calcitonin (CT). To identify a convenient source of CT-producing cells for studies of rat CT biosynthesis, the authors have propagated 16 transplantable series of medullary thyroid carcinoma (MTC) from 2 types of WAG/Rij rat MTC from The Netherlands. Tumor CT concentrations and growth and plasma CT accumulation were studied in successive transplant generations of each MTC series. Although most MTC series maintained characteristic predictable tumor CT levels, some MTC series acquired nearly 90% lower CT levels. While related MTC series tended to maintain similar predictable growth rates, several spontaneous and propagatable increases (up to 5-fold) in tumor growth rates were noted. These increases occurred with and without concomitant decreases in tumor CT. Tumor CT production ranged over 20-fold among these 16 MTC series. Serial plasma CT analyses can be used to estimate tumor growth and CT production in live MTC rats. Using serial plasma CT analyses, we can select for serial transplantation tumors with specific growth and CT characteristics. This should facilitate propagation of MTC series needed for particular studies of CT production and cancer.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalEndocrinology
Volume105
Issue number1
StatePublished - Dec 1 1979

Fingerprint

Calcitonin
Transplantation
Growth
Neoplasms
Medullary Thyroid cancer
Netherlands

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Roos, B. A., Yoon, M. J., Frelinger, A. L., Pensky, A. E., Birnbaum, R. S., & Lambert, P. W. (1979). Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma. Endocrinology, 105(1), 27-32.

Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma. / Roos, B. A.; Yoon, M. J.; Frelinger, A. L.; Pensky, A. E.; Birnbaum, R. S.; Lambert, P. W.

In: Endocrinology, Vol. 105, No. 1, 01.12.1979, p. 27-32.

Research output: Contribution to journalArticle

Roos, BA, Yoon, MJ, Frelinger, AL, Pensky, AE, Birnbaum, RS & Lambert, PW 1979, 'Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma', Endocrinology, vol. 105, no. 1, pp. 27-32.
Roos BA, Yoon MJ, Frelinger AL, Pensky AE, Birnbaum RS, Lambert PW. Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma. Endocrinology. 1979 Dec 1;105(1):27-32.
Roos, B. A. ; Yoon, M. J. ; Frelinger, A. L. ; Pensky, A. E. ; Birnbaum, R. S. ; Lambert, P. W. / Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma. In: Endocrinology. 1979 ; Vol. 105, No. 1. pp. 27-32.
@article{2b4c919547874bbcb5444a79f3ee942f,
title = "Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma",
abstract = "We have recently reported immunochemical methods for the measurement and purification of rat calcitonin (CT). To identify a convenient source of CT-producing cells for studies of rat CT biosynthesis, the authors have propagated 16 transplantable series of medullary thyroid carcinoma (MTC) from 2 types of WAG/Rij rat MTC from The Netherlands. Tumor CT concentrations and growth and plasma CT accumulation were studied in successive transplant generations of each MTC series. Although most MTC series maintained characteristic predictable tumor CT levels, some MTC series acquired nearly 90{\%} lower CT levels. While related MTC series tended to maintain similar predictable growth rates, several spontaneous and propagatable increases (up to 5-fold) in tumor growth rates were noted. These increases occurred with and without concomitant decreases in tumor CT. Tumor CT production ranged over 20-fold among these 16 MTC series. Serial plasma CT analyses can be used to estimate tumor growth and CT production in live MTC rats. Using serial plasma CT analyses, we can select for serial transplantation tumors with specific growth and CT characteristics. This should facilitate propagation of MTC series needed for particular studies of CT production and cancer.",
author = "Roos, {B. A.} and Yoon, {M. J.} and Frelinger, {A. L.} and Pensky, {A. E.} and Birnbaum, {R. S.} and Lambert, {P. W.}",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "105",
pages = "27--32",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Tumor growth and calcitonin during serial transplantation of rat medullary thyroid carcinoma

AU - Roos, B. A.

AU - Yoon, M. J.

AU - Frelinger, A. L.

AU - Pensky, A. E.

AU - Birnbaum, R. S.

AU - Lambert, P. W.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - We have recently reported immunochemical methods for the measurement and purification of rat calcitonin (CT). To identify a convenient source of CT-producing cells for studies of rat CT biosynthesis, the authors have propagated 16 transplantable series of medullary thyroid carcinoma (MTC) from 2 types of WAG/Rij rat MTC from The Netherlands. Tumor CT concentrations and growth and plasma CT accumulation were studied in successive transplant generations of each MTC series. Although most MTC series maintained characteristic predictable tumor CT levels, some MTC series acquired nearly 90% lower CT levels. While related MTC series tended to maintain similar predictable growth rates, several spontaneous and propagatable increases (up to 5-fold) in tumor growth rates were noted. These increases occurred with and without concomitant decreases in tumor CT. Tumor CT production ranged over 20-fold among these 16 MTC series. Serial plasma CT analyses can be used to estimate tumor growth and CT production in live MTC rats. Using serial plasma CT analyses, we can select for serial transplantation tumors with specific growth and CT characteristics. This should facilitate propagation of MTC series needed for particular studies of CT production and cancer.

AB - We have recently reported immunochemical methods for the measurement and purification of rat calcitonin (CT). To identify a convenient source of CT-producing cells for studies of rat CT biosynthesis, the authors have propagated 16 transplantable series of medullary thyroid carcinoma (MTC) from 2 types of WAG/Rij rat MTC from The Netherlands. Tumor CT concentrations and growth and plasma CT accumulation were studied in successive transplant generations of each MTC series. Although most MTC series maintained characteristic predictable tumor CT levels, some MTC series acquired nearly 90% lower CT levels. While related MTC series tended to maintain similar predictable growth rates, several spontaneous and propagatable increases (up to 5-fold) in tumor growth rates were noted. These increases occurred with and without concomitant decreases in tumor CT. Tumor CT production ranged over 20-fold among these 16 MTC series. Serial plasma CT analyses can be used to estimate tumor growth and CT production in live MTC rats. Using serial plasma CT analyses, we can select for serial transplantation tumors with specific growth and CT characteristics. This should facilitate propagation of MTC series needed for particular studies of CT production and cancer.

UR - http://www.scopus.com/inward/record.url?scp=0018777108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018777108&partnerID=8YFLogxK

M3 - Article

C2 - 446409

AN - SCOPUS:0018777108

VL - 105

SP - 27

EP - 32

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 1

ER -