Tuberous sclerosis: Characteristics at CT and MR imaging

N. R. Altman, R. K. Purser, M. Judith Post

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Abstract

Computed tomography (CT) and magnetic resonance (MR) imaging findings were reviewed in 26 patients with tuberous sclerosis. All patients underwent CT; 16 patients underwent both. The CT features included subependymal nodules in 25 of 26 patients (96%) and calcifications in 23 of 26 (88%). Parenchymal hamartomas (cortical tubers) were seen in 23 of 26 patients (88%). These lesions had less attenuation than surrounding brain in 16 of 26 patients (62%) and were calcified in 14 of 26 patients (54%). Contrast enhancement of a lesion, indicating a subependymal giant cell astrocytoma, occurred in three of 26 patients (12%). The MR imaging characteristics included subependymal nodules (periventricular nodules) of intermediate signal intensity in ten of the 16 patients (63%). Parenchymal hamartomas, demonstrated in 15 of the 16 patients (94%), usually exhibited long T1 and T2 relaxation characteristics. The pattern was noted to be reversed in the two newborn patients (13%). One parent demonstrated a forme fruste at CT but had a normal MR image.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalRadiology
Volume167
Issue number2
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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Altman, N. R., Purser, R. K., & Judith Post, M. (1988). Tuberous sclerosis: Characteristics at CT and MR imaging. Radiology, 167(2), 527-532.