Tubal sterilization and risk of cancer of the endometrium

James V. Lacey, Louise A. Brinton, Rodrigue Mortel, Michael L. Berman, George D. Wilbanks, Leo B. Twiggs, Rolland J. Barrett

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective. Surgical sterilization is a common method of contraception among U.S. women. Most surgical sterilizations are tubal ligations, but few studies have investigated their potential impact on endometrial cancer risk. Methods. A case-control study included 405 women diagnosed with endometrial cancer at 5 U.S. medical centers between 1987 and 1990 and 297 age-, race-, and location-matched controls who were identified by random-digit-dialing. Questionnaires ascertained information on tubal sterilization, and logistic regression models generated odds ratios (ORs) to estimate relative risk. Results. The OR and 95% confidence interval for tubal sterilization, which was reported by 47 cases and 40 controls, was 0.9 (0.6-1.4) before adjustment and 1.4 (0.8-2.4) after adjustment for age, parity, and oral contraceptive use. Age at surgery, years since surgery, or calendar years of surgery were not associated with endometrial cancer, and associations did not vary according to parity or stage of disease at diagnosis. Conclusions. Tubal sterilization is not substantially associated with endometrial cancer. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)482-484
Number of pages3
JournalGynecologic Oncology
Volume79
Issue number3
DOIs
StatePublished - Dec 23 2000
Externally publishedYes

Fingerprint

Tubal Sterilization
Endometrial Neoplasms
Parity
Logistic Models
Odds Ratio
Oral Contraceptives
Contraception
Case-Control Studies
Confidence Intervals

Keywords

  • Endometrial cancer
  • Surgical sterilization
  • Tubal sterilization

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Lacey, J. V., Brinton, L. A., Mortel, R., Berman, M. L., Wilbanks, G. D., Twiggs, L. B., & Barrett, R. J. (2000). Tubal sterilization and risk of cancer of the endometrium. Gynecologic Oncology, 79(3), 482-484. https://doi.org/10.1006/gyno.2000.5970

Tubal sterilization and risk of cancer of the endometrium. / Lacey, James V.; Brinton, Louise A.; Mortel, Rodrigue; Berman, Michael L.; Wilbanks, George D.; Twiggs, Leo B.; Barrett, Rolland J.

In: Gynecologic Oncology, Vol. 79, No. 3, 23.12.2000, p. 482-484.

Research output: Contribution to journalArticle

Lacey, JV, Brinton, LA, Mortel, R, Berman, ML, Wilbanks, GD, Twiggs, LB & Barrett, RJ 2000, 'Tubal sterilization and risk of cancer of the endometrium', Gynecologic Oncology, vol. 79, no. 3, pp. 482-484. https://doi.org/10.1006/gyno.2000.5970
Lacey JV, Brinton LA, Mortel R, Berman ML, Wilbanks GD, Twiggs LB et al. Tubal sterilization and risk of cancer of the endometrium. Gynecologic Oncology. 2000 Dec 23;79(3):482-484. https://doi.org/10.1006/gyno.2000.5970
Lacey, James V. ; Brinton, Louise A. ; Mortel, Rodrigue ; Berman, Michael L. ; Wilbanks, George D. ; Twiggs, Leo B. ; Barrett, Rolland J. / Tubal sterilization and risk of cancer of the endometrium. In: Gynecologic Oncology. 2000 ; Vol. 79, No. 3. pp. 482-484.
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