Abstract
Seven patients who developed a syndrome of eosinophilia, connective-tissue disease, and cutaneous abnormalities while ingesting tryptophan were examined. Other clinical manifestations commonly seen were pulmonary symptoms, fever, lymphadenopathy, and the development of myopathy. Laboratory features included mild elevations of aldolase and lactate dehydrogenase levels, with essentially normal creatine kinase levels, erythrocyte sedimentation rates, and C-reactive protein levels. Biopsy findings included features of scleroderma, small-vessel vasculitis, fasciitis, and myopathy. Discontinuation of tryptophan administration and implementation of corticosteroid therapy were of some benefit in relieving the intense myalgias and cutaneous findings that developed. Although temporally related to tryptophan ingestion, it is unclear whether this substance, a metabolite, or a contaminant were causal. We speculate that the pathogenesis of this syndrome may relate to abnormalities in tryptophan metabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 1502-1506 |
| Number of pages | 5 |
| Journal | Journal of the American Medical Association |
| Volume | 263 |
| Issue number | 11 |
| State | Published - Mar 16 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Tryptophan-associated eosinophilic connective-tissue disease : A new clinical entity? / Clauw, Daniel J.; Nashel, David J.; Umhau, Andrew; Katz, Paul.
In: Journal of the American Medical Association, Vol. 263, No. 11, 16.03.1990, p. 1502-1506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tryptophan-associated eosinophilic connective-tissue disease
T2 - A new clinical entity?
AU - Clauw, Daniel J.
AU - Nashel, David J.
AU - Umhau, Andrew
AU - Katz, Paul
PY - 1990/3/16
Y1 - 1990/3/16
N2 - Seven patients who developed a syndrome of eosinophilia, connective-tissue disease, and cutaneous abnormalities while ingesting tryptophan were examined. Other clinical manifestations commonly seen were pulmonary symptoms, fever, lymphadenopathy, and the development of myopathy. Laboratory features included mild elevations of aldolase and lactate dehydrogenase levels, with essentially normal creatine kinase levels, erythrocyte sedimentation rates, and C-reactive protein levels. Biopsy findings included features of scleroderma, small-vessel vasculitis, fasciitis, and myopathy. Discontinuation of tryptophan administration and implementation of corticosteroid therapy were of some benefit in relieving the intense myalgias and cutaneous findings that developed. Although temporally related to tryptophan ingestion, it is unclear whether this substance, a metabolite, or a contaminant were causal. We speculate that the pathogenesis of this syndrome may relate to abnormalities in tryptophan metabolism.
AB - Seven patients who developed a syndrome of eosinophilia, connective-tissue disease, and cutaneous abnormalities while ingesting tryptophan were examined. Other clinical manifestations commonly seen were pulmonary symptoms, fever, lymphadenopathy, and the development of myopathy. Laboratory features included mild elevations of aldolase and lactate dehydrogenase levels, with essentially normal creatine kinase levels, erythrocyte sedimentation rates, and C-reactive protein levels. Biopsy findings included features of scleroderma, small-vessel vasculitis, fasciitis, and myopathy. Discontinuation of tryptophan administration and implementation of corticosteroid therapy were of some benefit in relieving the intense myalgias and cutaneous findings that developed. Although temporally related to tryptophan ingestion, it is unclear whether this substance, a metabolite, or a contaminant were causal. We speculate that the pathogenesis of this syndrome may relate to abnormalities in tryptophan metabolism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025350852&partnerID=8YFLogxK
M3 - Article
C2 - 2308182
AN - SCOPUS:0025350852
VL - 263
SP - 1502
EP - 1506
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 11
ER -